The weekend news reports: March 28, 2009


Today’s reports include information on:

  • Percentage of positive biopsy cores as a predictor for extraprostatic disease
  • The RALP learning curve
  • A surgical modification that improves recovery of continence
  • Radiation toxicity associated with HDR brachytherapy + EBRT

In a separate report we have dealt with a paper on the use of salvage brachytherapy for men with biochemical recurrence following first-line external beam radiation therapy.
Mortensen et al. have confirmed, in a Danish patient cohort, that the percentage of positive biopsy cores is an independent predictor of risk for extraprostatic disease. (We note that this information is already incorporated in the Kattan nomogram commonly used in the USA.)

Tsao et al. have reported their experience in treatment of the first 100 patients using robot-assisted laparoscopic prostatectomy (RALP) over a 34-month period at a major academic teaching hospital in the USA.

Porpiglia et al. have reported data  from a small, randomized, prospective clinical trial showing that, by using a technique known as “selective ligature of the deep venous complex” (SLDVC), they were able significantly increase the percentage of patients who recovered continence within 3 months of surgery (from 53 to 80 percent) as compared to those patients in whom a standard ligature of the deep venous complex was carried out.

Ishiyama et al. have reported the risk for relatively high levels of acute and late genitourinary (GU) toxicities in patients receiving high dose rate (HDR) brachytherapy in combination with external beam radiotherapy. In their series of 100 Japanese patients, 6/100 displayed Grade 3 acute GU toxicity, and 12/100 displayed Grade 3 late GU toxicity.

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