Impact of taldalafil once daily on sexual quality of life

According to a media release from Eli Lilly and Company late yesterday, a double-blind, placebo-controlled study has shown that tadalafil (Cialis) 5 mg taken once daily improved erectile function for men with erectile dysfunction (ED) and reported improvement in the sexual quality of life scores for men and their female partners.

We should note immediately, however, that this study excluded men with ED associated with prostate cancer treatment. It is well understood that 5PDE inhibitors like taldalafil do not work for all men with ED that is a consequence of prostate cancer treatment.

The really interesting this about this trial (which enrolled 342 men and their partners, and used validated questionnaires to assess changes in erectile function and sexual quality of life before and after treatment), however, is that “This is the first study … in which the female partner reported improvement in sexual quality of life scores,” according to Eusebio Rubio-Aurioles MD, PhD, the lead investigator.

The study was published in the May issue of the Journal of Sexual Medicine. Specific results of this study were as follows:

  • Tadalafil 5 mg taken daily significantly improved erectile function according to changes from baseline.
  • The average increase from baseline to endpoint using the IIEF-EF domain was 7.9 points in the tadalafil group, compared with 0.7 points in the placebo group.
  • Men in the tadalafil group reported a 28.6 percent increase on average (compared with 2.7 percent in the placebo group) in the ability to achieve an erection sufficient for vaginal penetration.
  • When asked if their erections lasted long enough for successful intercourse, men in the tadalafil group reported a 46 percent increase on average in positive responses from baseline to endpoint, compared with 10.8 percent in the placebo group.
  • The average increase in Sexual Quality of Life (SQoL) scores from baseline to endpoint for men in the tadalafil group was 39.5 points, compared with12.5 point increase in the placebo group.
  • The average increase in SQoL scores for women whose partners were in the tadalafil group was 32.4 points, compared with 5 points in the placebo group.
  • Tadalafil 5 mg was generally well-tolerated, and the most frequently reported adverse events were headache, dyspepsia and nasal congestion.
  • Three subjects in the tadalafil group discontinued participation in the study due to adverse events.

2 Responses

  1. My husband is on Zoladex and has no libido. I wonder if men were to take Cialis from the start of their treatment whether this would help these men also.

  2. Dear Jennie:

    Unfortunately, while drugs like Cialis can assist men to get and maintain erectile function, they cannot overcome the problem of lack of libido associated with treatment with Zoladex and other LHRH agonists. We need to find better drugs that can control the effects of testosterone on development of prostate cancer without impacting libido — but this is a complex challenge.

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