Prostate cancer news reports: Saturday, June 13, 2009

Today’s news reports include information on:

  • Outcomes comparing two types of radiation therapy
  • Outcomes of younger vs. older men after radical prostatectomy
  • The activity and safety of AZD0530 in CRPC

Leborgne and Fowler report that, based on data from a non-randomized, contemporary comparative study of 219 patients with localized prostate cancer at a single institution, 5-year outcomes after hypofractionated conformal radiotherapy (n = 89) were almost exactly the same as those from treatment with standard fractionation (n = 130).

Pfitzenmaier et al. have studied the impact of age on survival after radical prostatectomy by comparing outcomes between men of < 70 (n = 526) and ≥ 70 years of age (n = 100) in a single prospective series. They report that, to all intens and purposes, there were no differences between the two groups of patients: the 10-year PSA-free survival for young and old patients was 51.8 and 57.4 percent; the 10-year disease-specific survival was 92.3 and 97.6 percent; the 10-year metastasis-free survival was 86.9 and 89.7 percent; and the  10-year overall survival was 78.1 and 71.2 percent (P = 0.565). The authors conclude that, for a well-selected, healthy, elderly population, survival outcomes are no worse than those seen in younger patients.

According to Lara et al., a Phase II study of the Src-kinase inhibitor AZD0530 in patients with castration-resistant prostate cancer (CRPC) shows that this new agent is safe but has minimal activity as a single agent in patients with very late stage disease. Futher studies will investigate whether there is activity in earlier stage disease.

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