Adjuvant ADT after surgery in men with high-risk prostate cancer

Back in June 2010, we reported on the initial results of SWOG 9921 — a trial that randomized 983 men with high-risk features at prostatectomy to receive adjuvant therapy with androgen deprivation (ADT) alone or in combination with mitoxantrone chemotherapy.

Available data from this trial have now been published by Dorff et al. in the Journal of Clinical Oncology — at a median 4.4 years of follow-up as opposed to the 3.8 years at the time of presentation at the annual meetings of the American Urological Association (AUA) and the American Society of Clinical Oncology (ASCO) in 2010.

There appear to be no significant additional learnings from the published data as compared to the data originally reported at the AUA and ASCO meetings. We therefore suggest that interested readers refer to our original and detailed report on the data.

6 Responses

  1. Well I could be the 984th patient but I added adjuvant radiation to go with adjuvant ADT. I’m at 48 months still undetectable …

  2. Tony: That’s a very different therapeutic option.

  3. Original PSA score was 18.5 ng/ml 3+ years ago with few symptoms; routine check-up discovery. After the hormone injection and radiotherapy PSA went down to 1.8. Now risen to 2.8 ng/ml, and every couple of weeks 3 to 4 interruptions per night to urinate; otherwise no pain, no “leaks.” Ideas?

  4. Dear Fred:

    We suggest you join our social network, where you will be able to get feedback from some of the nearly 3,000 members of that network.

  5. Mike — your link in the last line takes me to the PubMed article on interim results for the ADT-alone arm, not your comments.

    Do we have any indication yet whether the addition of the chemo made a difference.

    I have recently been conversing with a guy who was on the early docetaxel trial; his PSA is back up after around 3 years.


  6. Rick: The link is now corrected. Sorry.

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