Oncothyreon enrolls first patient in Phase II trial of PX-866 for CRPC


Oncothyreon, Inc. has announced initiation of a Phase II clinical trial of the company’s investigational agent PX-866 in the treatment of men with chemotherapy-naïve, recurrent or metastatic, castration-resistant prostate cancer (CRPC). The trial is being conducted by the NCIC Clinical Trials Group (NCIC CTG), headquartered at Queen’s University in Kingston, Ontario, Canada.

PX-866 is an inhibitor of an important cell signaling pathway that is commonly activated in many types of human cancer (the so-called PI-3K/PTEN/AKT pathway). Abnormal activation and regulation of phosphoinositide 3-kinase (PI-3K) occurs in several human cancers. Such abnormal activation and regulation can lead to proliferation of cancer cells and inhibition of programmed cell death (apoptosis). PX-866 is a small molecule that can be taken orally. More information about this drug can be found on the Oncothyreon web site.

Detailed information about this clinical trial is available on the ClinicalTrials.gov web site. The trial is already enrolling patients but is open exclusively to men with castration-resistant prostate cancer who have received no prior chemotherapy treatment for recurrent disease. It is not yet entirely clear at which centers in Canada that patients can be enrolled into this trial.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this: