Phase II trial of sipuleucel-T + indoximod in mCRPC


NewLink Genetics is to conduct an investigator-initiated, randomized, double-blind, placebo-controlled, Phase II trial of sipuleucel-T + indoximod (D-1MT/NLG8189) in the treatment of men with asymptomatic or minimally symptomatic, metastatic, castration-resistant prostate cancer (mCRPC).

According to the media release on the Yahoo!Finance web site, this study with be conducted in collaboration with Dendreon Corporation and the Masonic Cancer Center at the University of Minnesota.

Indoximod is a so-called IDO pathway inhibitor and affects expression of the IDO enzyme that regulates immune response by suppressing T-cell function and enabling local tumor immune escape. Some more information about this product is available on the NewLink Genetics web site. The details about this trial are not yet posted to the ClinicalTrials.gov web site. For more information you will currently need to contact NewLink Genetics by phone (515-296-5555) or by e-mail.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this: