“One drug to shrink all tumors”

An article with the above headline appears on the Science web site this week. It refers to the apparent biological effects of an antibody known as anti-CD47 and work on the development of this agent by Irving Weissman and colleagues at Stanford University School of Medicine.

For those interested in drug development and the treatment of cancer, this article it is well worth a quick read. However, research to date is limited to the effects of anti-CD47 on human tumors transplanted into highly genetically defined mice in the research laboratory. As a commentator is quoted as stating in the article,

The microenvironment of a real tumor is quite a bit more complicated than the microenvironment of a transplanted tumor.

This is far from being the first time that we have observed extremely promising effects of potential new drugs in laboratory mice. Unfortunately, all too often, such effects are not apparent when these drugs are tested in men (and women).

Hope is good; wisdom requires a balance of hope and reality. Dr. Weissman believes it should be possible to start Phase I clinical trials with anti-CD47 in the near future. Then we may start to learn more.

One Response

  1. Thank you for this article. I know so many people who are affected by prostate cancer. My husband has a family history of prostate cancer and he also suffers from some of the effects of an enlarged prostate.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this: