Mapping biopsies vs mpMRI vs Prostate Histoscanning technology

According to a recently published article, European researchers are initiating a new study to explore the ability of multi-parametic MRIs (mpMRI) and the Prostate HistoScanning™ (PHS) technique to rule out risk for clinically significant prostate cancer.

The new trial, known as the Prostate Imaging … Compared to Transperineal Ultrasound-guided biopsy for significant prostate cancer Risk Evaluation or PICTURE study, is being conducted in the UK and is already enrolling patients. Enrollment is expected to be complete by the end of 2014. The abstract of the paper by Simmons et al. describing this trial is available on line. Additional information is available on the web site.

The PICTURE study expects to enroll about 125 patients. According to the study outline, this prospective study will be able to provide Level 1 evidence regarding the negative predictive value of mpMRI and PHS compared to template-based, transperineal mapping biopsies. Men with a suspicious lesion or lesions on the basis of mpMRI or PHS will undergo targeted biopsies to assess the clinical utility of sampling only the suspicious areas.

This appears to be a potentially important trial in the evolution of our knowledge about whether imaging techniques can be used to replace biopsy-based methods in the identification of men who need treatment for prostate cancer.

For readers who have yet to come across the Prostate HistoScanning technology (which is approved by the FDA but not widely used to date), please click here to get more information.

One Response

  1. Just to inform your readers, HistoScanning is NOT yet FDA approved, as far as I am aware.

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