Treatment regret among men with recurrent prostate cancer


The issue of treatment regret comes up regularly among men after first-line treatment for localized prostate cancer, but has been less commonly addressed among men with recurrent disease post-treatment.

Mahal et al. used data from the prospective Comprehensive, Observational, Multicenter, Prostate Adenocarcinoma (COMPARE) registry to study treatment regret among men with biochemically recurrent prostate cancer after first-line treatment with radical prostatectomy, external beam radiation, or brachytherapy. In particular, they were interested in looking at the impact of race on treatment regret among men in this study cohort.

Here is a summary of their findings:

  • The study cohort included a total of 484 men.
  • Treatment regret was expressed by
    • 21.8 percent of 78 black males
    • 12.6 percent of 406 non-black males
  • This difference was significant on univariate analysis (odds ratio [OR] = 1.94; P = 0.03).
  • This difference trended toward but was not significant on multivariate analysis (adjusted OR = 1.84; P = 0.071).
  • Among men without sexual problems post-treatment, black men had more treatment regret than non-black men (26.7 vs 8.4 percent; adjusted OR = 4.68; P = 0.002).
  • Among men with sexual problems post treatment, there was no difference in treatment regret between black and non-black men (18.8 vs 17.3 percent; adjusted OR = 1.04; P = 0.93).

Mahal et al. conclude that:

Among men with recurrent prostate cancer after surgery or radiation, black men were nearly twice as likely to experience treatment regret. Treating physicians should ensure that patients are fully apprised of the pros and cons of all treatment options to reduce the risk of subsequent regret.

One Response

  1. Just based on the anecdotal evidence re all the prostate cancer forums and articles I read, I would imagine the percentage of treatment regret is up there. …

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