Will restriction spectrum imaging replace multiparametric MRI?


Researchers at the University of California San Diego have developed a new kind of MRI called restriction spectrum imaging MRI or just RSI-MRI that seems to discriminate among Gleason grades 3, 4, and 5 with unmatched geographic precision.

Yamin et al. report on data from 10 prostates that were scanned with RSI-MRI prior to prostatectomy. The prostates were then stained and tumors in them were examined at high resolution. (High resolution, in this study, was 75 micrometers per pixel). In all, 2,795 microscopic “tiles,” grouped to be the size of the MRI voxel, were examined by pathologists and assigned Gleason grades. (An MRI voxel is the minimum volume of matter that can resolved by an MRI.) They found that:

  • RSI-MRI distinguished between cancer and benign tissue.
  • RSI-MRI distinguished between Gleason grade 3 and benign tissue.
  • RSI-MRI distinguished between Gleason grade 4 and benign tissue.
  • RSI-MRI distinguished between Gleason grade 3 and Gleason grade 4
  • It distinguished grades with geographic precision down to the voxel level

In a retrospective evaluation of 33 pre-prostatectomy patients, RSI-MRI was found to more accurately predict prostate cancer and was more highly correlated with Gleason grade. In a similar retrospective evaluation of 28 pre-prostatectomy patients, both RSI-MRI and mpMRI were able to predict the primary Gleason grade across 64 regions of interest. However, RSI-MRI, but not mpMRI, could distinguish primary Gleason grade 3 from Gleason 4. In a group of 100 patients with Gleason scores ≥ 4 + 3, RSI-MRI significantly improved the accuracy compared to mpMRI alone. When combined with only a T2-weighted MRI, it compared favorably to mpMRI.

By comparison, a multiparametric MRI (mpMRI) does a very poor job at distinguishing Gleason grade 3 from benign tissue, and it is geographically much less precise. Even with mpMRI/ultrasound fusion repeat biopsies, known areas of cancer are missed about 30% of the time in men on active surveillance.

It may be a superior tool for staging as well. The same group of investigators reported on 27 pre-prostatectomy patients who were staged with MRI and with RSI-MRI. Extraprostatic extension was correctly identified in only 2/9 patients (22 percent) using MRI, but in 8/9 patients (89 percent) using RSI-MRI. It also correctly staged the remaining 18 patients.

To understand this technique, a brief review of multiparametric MRI is in order. Multiparametric MRI, as most commonly used for prostate cancer detection, employs three parameters (there are other parameters, like MR spectroscopy, that are less commonly used):

  1. T2 weighting shows areas of different tissue types. Bone, fat, air, calcifications, fibrosis are dark; whereas edema, tumors, and inflammation are light. This shows the basic anatomic detail for the other parameters to be fused with.
  2. Dynamic contrast-enhanced (DCE) MRI uses a gadolinium dye to show areas of blood flow. Tumors often have increased blood supply (called angiogenesis) that does not penetrate well. Because DCE has a relatively low signal-to-noise ratio, features can be difficult to distinguish.
  3. Diffusion-weighted (DWI) MRI shows water circulation in and around cells due to the water molecules’ Brownian (random) motion. Water flows easily around the glandular tissue of a healthy prostate, but as dense tumor cells proliferate, the fluid flow is hindered. These images suffer from spatial distortion, making precise localization for biopsies difficult. Obstacles created by inflammation and necrosis can create false positives.

 

RSI picks up where DWI leaves off. It detects water molecule motion within the cells. Unlike the hindered motion of water molecules around the outside of cells, cell walls restrict the motion of water molecules within their perimeter. As cancer cells proliferate in the tumor, there is increasing restriction detected. Unlike DWI, RSI does not suffer from spatial distortion and the signal-to-noise ratio is much higher; therefore, tumors stand out in sharper relief. It is unaffected by prostatitis and other tissue anomalies. There is also much less overlap in its ability to distinguish Gleason grades.

Compared to an mpMRI, which takes about an hour, it also takes much less time to acquire the images with RSI-MRI. It is probably less subject to reader error as well. It is easy to see how this can become an important tool in monitoring progression in men on active surveillance, detecting cancer in men where suspicion remains after a first negative biopsy, and in detecting the tumor site for focal therapy and for focal salvage therapy after primary radiation or ablation therapy.

RSI-MRI was originally developed to detect and precisely localize brain tumors, and its use for prostate tumor detection is still in its early stages. We will have to have larger prospective trials to validate its use.

Editorial note: This commentary was written for The “New” Prostate Cancer InfoLink by Allen Edel.

7 Responses

  1. This is wonderful news! Thanks Allen🤗

  2. Is the RSI MRI available for patients now?

  3. No, it’s not available yet. As I said, it has to be validated in larger prospective trials first. I haven’t seen any clinical trials announced yet.

  4. I believe it is available now. Recently completed MRI at the new MRI facility and was told it was RSI. At the time I did not understand the important implications of RSI, but will double back to speak with my radiation oncologist, Dr. Einck and/or the radiologist.

  5. I checked with UCSD. They said, “all patients at UCSD get RSI-MRI when they are scanned here for prostate cancer work-up.”

  6. Thanks for this summary of a potentially very important technique.

  7. Great content and breakdown here. Thank you for sharing. Keep up the good work.

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