First randomized clinical trial of SBRT reports primary outcome

In the first trial ever to randomly assign patients to extreme hypofractionation, primary radiation therapy delivered in just seven treatments had the same effectiveness and safety as 39 treatments. … READ MORE …

Toxicity equal for SBRT and conventional external beam radiation (3D-CRT)

There has been some question as to whether the toxicity of delivering very high doses of external beam radiation per treatment (or fraction) in fewer fractions (called “extreme hypofractionation” or SBRT) would be high compared to conventional dose rates per fraction. … READ MORE …

IMRT probably no better than 3D-CRT after radical prostatectomy

In another relatively unsurprising finding, a paper in JAMA Internal Medicine has suggested that– from a clinical point of view — there is little difference in the outcomes of men treated with older rather than newer forms of radiation therapy after first-line surgery for localized prostate cancer. … READ MORE …

Relative value of 3D-CRT, IMRT, and PBRT in prostate cancer published in JAMA

In February we reported on a presentation by Sheets et al. at the Genitourinary Cancer Symposium. The presentation addressed the comparative effectiveness and safety of  3D conformal, intensity-modulated, and proton beam forms of radiation therapy (3D-CRT, IMRT, and PBRT, respectively). … READ MORE …

All the different types of external beam radiation therapy for prostate cancer: a good introduction

Over the past 20 years there has been an explosion in the different ways that we use varied types of external beam radiation therapy for the treatment of localized and locally advanced forms of prostate cancer. Where is the newly diagnosed patient able to find a good, basic introduction? … READ MORE …

GI toxicity, radiation therapy, and androgen deprivation

For men undergoing the combination of external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT), for treatment of prostate cancer there is a significant risk for gastrointestinal (GI) toxicity over time. … READ MORE …

Slightly fewer (severe) complications after IMRT compared to CRT

According to a media release from the University of Pennsylvania Health System, (and another from the American Society of Radiation Oncology [ASTRO]), intensity-modulated radiation therapy (IMRT) is associated with fewer complications than traditional, three-dimensional conformal radiation therapy (3D-CRT) in the treatment of non-metastatic prostate cancer. … READ MORE …

Chemohormonal therapy + EBRT for treatment of locally advanced prostate cancer

Several years ago, Bolla et al. planned and carried out the major European trial showing that external beam radiation therapy with 3 years of androgen deprivation therapy (ADT, using goserelin acetate)  extended the prostate cancer-specific and the overall survival of patients with high-risk localized prostate cancer as compared to radiation alone. … READ MORE …

CT + ADT vs. 3D-CRT + ADT for first-line treatment of “high-risk” prostate cancer

A South Korean research team has just published data from a small, prospective, case-matched study comparing outcomes after cryotherapy + androgen deprivation therapy (CT + ADT) to outcomes after three-dimensional conformal radiation therapy + androgen deprivation (3D-CRT + ADT) in patients with high-risk prostate cancer. … READ MORE …

More on the value of HDR brachytherapy added to EBRT

A few days ago we reported on a study which concluded that the addition of high-dose-rate (HDR) brachytherapy to intensity-modulated radiation therapy (IMRT) had limited short-term clinical benefit in the treatment of localized prostate cancer compared to IMRT alone. Newly published Australian data is arguably supportive of this viewpoint. … READ MORE …