Early data on the accuracy and potential of the 4Kscore test

The late-breaking abstract for the results of a US-based study of the accuracy of the new 4Kscore Test™ has just been made available on  line. … READ MORE …

Just how good is multiparametric, 3-T MRI at finding, staging localized disease?

It is clear that modern magnetic resonance imaging is getting closer to being able to make a major difference to the way that we diagnose (and potentially manage) localized prostate cancer … always assuming we can afford the costs involved (at least here in the USA). … READ MORE …

Detection of sites of prostate cancer recurrence after first-line EBRT

A newly published report from a group of Italian researchers provides us with some further data on the accuracy of [11C]choline PET/CT scanning in the detection of recurrent prostate cancer — in this case in men who recur after first-line external beam radiation therapy (EBRT). … READ MORE …

The accuracy of [11C]choline PET/CT scans in actual clinical practice

Although [11C]choline PET scans have been a “hot” developing tool for the identification of sites of recurrence of prostate cancer after first-line treatment, we have few data as yet confirming the accuracy of these scans through pathology. … READ MORE …

mpMRI scans before biopsy, mpMRI-guided biopsies recommended in UK

An article in The Daily Telegraph in the UK this morning addresses a variety of issues related to the difficulties associated with the use of TRUS-guided prostate biopsy to diagnose localized and locally advanced prostate cancer. … READ MORE …

More data on accuracy of the PCA3 test in the real world

The prostate cancer gene 3 or PCA3 test has been approved exclusively as a means to assess the potential value of a repeat biopsy for a man who has already had a negative biopsy but whose PSA values (and/or other indicators) continue to suggest significant risk for prostate cancer. … READ MORE …

The accuracy (and value) of MRI methods in diagnosis and prognosis of prostate cancer

Two recent studies are helpful in clarifying the issue of when specific types of magnetic resonance imaging (MRI) meothds may be useful in the diagnosis and prognosis of prostate cancer. … READ MORE …

Accurate identification of positive lymph nodes in men with progressive prostate cancer

One of the hardest things to be able to do, currently, in a man with progressive prostate cancer after first- or second-line therapy, is to determine his risk for lymph node-positive prostate cancer or LNPPC (i.e., one of the earliest  and more common components of metastatic prostate cancer). … READ MORE …

“No catheter” radical prostatectomy … Just how viable is this really?

According to a media release issued by the University of Cincinnati Health Center last Thursday, a urologist at that center is now offering patients robot-assisted laparoscopic prostatectomies (RALPs) without transurethral catheterization post-surgery. They describe this as a “no catheterization” technique. … READ MORE …

Tea drinking and risk for prostate cancer (in Scotland if nowhere else)

Back in the dim and distant past (i.e., the 1960s and 1970s), relatively high levels of tea consumption were common in most of the United Kingdom, and coffee was an uncommon substitute. This is certainly not so true today. However, … READ MORE …

The “best” way to measure post-treatment levels of urinary continence

A new paper published by researchers from Sweden’s prestigious Karolinska Institute and related institutions makes it increasingly clear that — to date — we haven’t been able to work out (let alone consistently use) a really good way to measure real urinary continence after radical prostatectomy. … READ MORE …

Accuracy and relevance of clinical stage in diagnosis and prognosis of localized prostate cancer

According to a new report from the University of California, San Francisco (to be published in Cancer this week), clinical staging errors may — at least in part — underlie the fact that the researchers were unable to demonstrate a clear link between clinical stage and risk for prostate cancer recurrence in patients initially diagnosed with localized prostate cancer. … READ MORE …

Limited predictive accuracy of endorectal coil MRI

Patients believed to be at potential risk for prostate cancer that may extend outside the prostate itself — through extracapsular extension (ECE) or seminal vesicle invasion (SVI) — often undergo imaging studies in planning for their treatment. Endorectal coil magnetic resonance imaging (erMRI) as been a commonly used form of such imaging. … READ MORE …

Another “strike” against saturation biopsies?

A new, detailed, correlative analysis of pathologic data from saturation biopsies as compared to the actual pathology of radical prostatectomy (RP) specimens has demonstrated that 90 percent of patients with apparent unilateral prostate cancer on biopsy really had bilateral disease. … READ MORE …

Your Wednesday news report: April 1, 2009

So let’s be completely clear … none of the items reported below are April Fool’s Day spoofs!

  • Oxidative damage to DNA and risk for prostate cancer
  • Accuracy of the Kattan nomograms whenb applied to non-US populations
  • Salvage radical prostatectomy in Brazil … READ MORE …