New data on the genetics of aggressive prostate cancer, but …

A new paper in the Proceedings of the National Academy of Sciences suggests the existence of a subset of “hypermutated” cell lines in some forms of aggressive prostate cancer. … READ MORE …

Diet and prostate cancer risk: a case-control study analysis

The idea that one’s diet may affect one’s risk for prostate cancer in general — or perhaps for one’s risk of more aggressive forms of prostate cancer — is not exactly new. … READ MORE …

The relative aggressiveness of prostate cancer in black and white patients

A newly published article, available on-line in the journal Prostate Cancer and Prostatic Diseases, shows that tissues from prostate biopsies from black men express higher levels of biomarkers for aggressive disease than do tissues from prostate biopsies taken from white men. … READ MORE …

Is SPINK1 the prostate cancer equivalent of HER2?

A team of researchers at the University of Michigan Comprehensive Cancer Center are claiming that they have identified an important target that may lead to the development of effective treatments for one aggressive type of prostate cancer. The target is a gene called SPINK1. … READ MORE …

Is CCP testing really the prognostic tool we need?

A new report just published on line in Lancet Oncology is suggesting that the cell cycle progression (CCP) score — a measure of the levels of expression of selected genes that are important to cell growth — may be an important indicator of risk for more aggressive types of prostate cancer. … READ MORE …

How often is a PSA test really needed to identify risk?

A re-analysis of data from the Antwerp (Belgium) section of the European Randomized Study of Screening for Prostate Cancer  (ERSPC) has offered us some further insight into the frequency of PSA testing necessary to identify less and more aggressive forms of prostate cancer. … READ MORE …

The aggressive treatment of high-risk localized and node-positive prostate cancer

Long-term follow-up data have just been published from two studies designed to provide preliminary information on the potential use of very aggressive forms of treatment in men with high-risk categories of prostate cancer. … READ MORE …

Why Ki-67 may not be USEFUL in predicting aggressive prostate cancer

A paper to be presented on Sunday at the upcoming annual meeting of the American Association for Cancer Research suggests that “the proliferative index as assessed by Ki-67 immunoreactivity is an independent predictor of aggressive prostate cancer.” … READ MORE …

Genetic variant “associated” with aggressive as compared to indolent forms of prostate cancer

Another new article in the Proceedings of the National Academy of Sciences has suggested the possibility of major progress in the prostate cancer research field — but at least this time the media seem to have got the story right! … READ MORE …

Cell cycle regulation and aggressive forms of prostate cancer

A new paper by Wang et al. in a recent issue of Cancer Research has proposed details of a specific connection between control over the growth and division of prostate cancer cells and clinical occurrence of the more aggressive forms of prostate cancer. … READ MORE …

New nomogram can predict aggressive recurrence after RP

Researchers associated with the Duke Prostate Cancer have re-calibrated an older nomogram (used to predict the likelihood of biochemical recurrence after a radical prostatectomy or RP). The revised nomogram is now capable of predicting not only biochemical recurrence but also the much more clinically significant risk for an aggressive recurrence — in which the post-surgical PSA doubling time (PSADT) is < 9 months. … READ MORE …

And now maybe Hsp-27 can be used to predict aggressive disease

Yesterday we reported a study suggesting the potential of hyalouronidase staining as a method to differentiate between aggressive and indolent prostate cancers at the time of diagnosis. Now a report in the British Journal of Cancer suggests that heat shock protein 27 (Hsp-27) may also have this potential. … READ MORE …

A viral etiology for aggressive forms of prostate cancer?

There have been frequent suggestions over the years that specific viruses may be implicated in the development of certain types of cancer, and an article in this week’s Proceedings of the National Academy of Science discusses the possibility that this may be the case in aggressive forms of prostate cancer. … READ MORE …

Vitamin A: new data imply potential for preventive effects

Now after you have read this, we do not think you should be rushing out to fill your medicine cabinet with vitamin A. We need more research to validate the results of this study, but … READ MORE …

Non-ASTRO-related news update: Thursday, September 25

Additional, non-ASTRO-related news today  includes the following:

  • Screening, treatment, and mortality in Medicare-eligible populations
  • Genetic variants and relationships to clinical and pathological variables
  • The application of MRI in prostate cancer management
  • Predictors of aggressive biochemical recurrence after radical prostatectomy … READ MORE …