ADT + EDT in the treatment of advanced prostate cancer?

An article published on line last year in Anticancer Research has just come to our attention. It puts forward the relatively simple proposal that by combining androgen deprivation therapy (ADT) with estrogen deprivation therapy (EDT) we might be able to significantly impact the risk for development of castration-resistant prostate cancer (CRPC). … READ MORE …

IADT — pro and con; a follow-up

The other day we mentioned two articles in a recent issue of JAMA Oncology that dealt with the role of intermittent androgen deprivation therapy (IADT) in the management of progressive prostate cancer today. We have now had the good fortune to be able to read both of the two articles in full, thanks to a kind correspondent. … READ MORE …

Starting the new year with two of the usual controversies

Strictly speaking, JAMA Oncology actually ended the old year (in its issue on December 29, 2016), rather than beginning the new one, with two articles, a letter to the editor, and an editorial that deal with two of the more controversial issues that affect the way we think about the management of prostate cancer. … READ MORE …

Serious pneumonia: yet another potential complication of treatment with ADT

It has been known for some time that androgen deprivation therapy (ADT) may increase risk for pneumonia because, normally, androgen levels have effects on how well the immune system works and on the health of lung tissue. … READ MORE …

Testosterone levels in patients on androgen deprivation therapy

For the past 40 years, the formal level of “effectiveness” of androgen deprivation therapy (ADT, also known as “hormone” therapy) for men treated for high-risk, progressive, and/or metastatic prostate cancer has been a serum testosterone level of < 50 ng/dl (equivalent to < 1.7 nmol/l). However, … READ MORE …

Can bipolar cycling of testosterone really cure prostate cancer?

Some readers will already have seen headlines like this one from The Vancouver Sun and/or this one from Fox News (which originally seems to have come from The Sun in the UK). … READ MORE …

ADT and risk for diagnosis with dementia? “Not in the UK”, they say!

Just a few weeks ago we reported data from a study in California suggesting an association between treatment with androgen deprivation therapy (ADT) for prostate cancer and subsequent risk for diagnosis with dementia or Alzheimer’s disease. … READ MORE …