ADT is associated with risk for Alzheimer’s and dementia in largest study to date

According to the newest and largest known analysis of data currently available, there is a small but statistically significant association between treatment with androgen deprivation therapy (ADT) and increase in risk for Alzheimer’s disease and/or dementia over time. … READ MORE …

Is PTEN loss a risk factor for progression of men on active surveillance?

A newly published paper in the journal Prostate Cancer and Prostatic Diseases has explored the above question based on data from the Johns Hopkins active surveillance (AS) cohort of men with initially low- or very low-risk prostate cancer. … READ MORE …

Is overall survival a useful endpoint for evaluating therapies for intermediate-risk patients?

In a recent commentary, we looked at the utility of surrogate endpoints in evaluating therapies. … READ MORE …

Prostate cancer, BPH, risk association, and a 3 million man study

A commonly raised question is whether men with benign prostatic hyperplasia (BPH) are at greater risk for prostate cancer than men who have no sign of BPH. A new, nation-wide study of the male population of Denmark over the past 27 years offers us some insights. … READ MORE …

Genetic markers for prostate cancer in Japanese patients

A large study of genetic markers in Japanese prostate cancer patients has clearly shown that some of the markers of prostate cancer in Caucasians do not appear in Japanese patients whereas new markers appear to be common among Japanese. … READ MORE …

Genetic variant “associated” with aggressive as compared to indolent forms of prostate cancer

Another new article in the Proceedings of the National Academy of Sciences has suggested the possibility of major progress in the prostate cancer research field — but at least this time the media seem to have got the story right! … READ MORE …

Is the TMPRSS2-ERG marker for prostate cancer clinically relevant?

We have long cautioned about whether the presence of apparent biologic “markers” in men with prostate cancer (“association”) is necessarily an implication that a specific marker really indicates anything clinically important. A paper published by a European team now helps to put this in perspective. … READ MORE …

What our genes aren’t telling us … yet!

An  important paper has just been published by a highly respected team of specialists doing research into the role of genetic variations in assessment of risk for prostate cancer. … READ MORE …