Use of bisphosphonate therapy in men on ADT in Ontario, Canada

According to a research letter published in the Journal of the American Medical Association, most men in Ontario, Canada, who have androgen deprivation therapy (ADT) for treatment of prostate cancer have not been receiving bisphosphonate or comparable therapy. … READ MORE …

Bisphosphonates in management of osteoporosis: an FDA update

Last Friday a U.S. Food & Drug Administration (FDA) advisory committee recommended (based on a 17 to 6 vote) that the labeling of bisphosphonates needed to be updated to make it clear how long patients should take these drugs to gain the greatest benefit and suffer the least risk. … READ MORE …

Risedronate prevents bone loss in patients on hormone therapy

A new study has shown that the generically available, oral, bisphosphonate risedronate (Actonel) can prevent bone loss and related effects in patients receiving hormonal therapy for prostate cancer. … READ MORE …

Preventing fractures in older patients on ADT

Men with prostate cancer who are 70 years of age or older, and who are starting adjuvant androgen deprivation therapy (ADT) for locally advanced or high-risk localized prostate cancer, should receive a bone mineral density (BMD) test followed by selective bisphosphonate therapy for those with osteoporosis, according to an article in today’s issue of Annals of Internal Medicine. … READ MORE …

Prostate cancer news reports: Tuesday, April 20, 2010

In today’s news reports we note new articles dealing with:

  • Biopsy protocols, patient selection, and focal therapy
  • Tertiary Gleason pattern 4/5 and risk for progression post-RP
  • Evolving data on the uses of bisphosphonates and denosumab
  • SKIs in treatment of advanced forms of prostate cancer … READ MORE …

Oral clodronate extends prostate cancer survival …

… by 23 percent, but only in combination with hormone therapy in men with metastatic disease, and in a relatively small trial. … READ MORE …

Bisphosphonate therapy and osteonecrosis of the jaw

Many prostate cancer patients are advised to use bisphosphonate therapy to prevent bone loss and other bone-related adverse events associated with long-term hormonal therapy. A disorder now known as bisphosphonate-related osteonecrosis of the jaw (BRONJ) was initially associated with bisphosphonate therapy in 2003-04 and there has been extensive research on this relationship since that date. … READ MORE …

Furore about Fosamax

There has been a lot of media noise in the past few days about two studies suggesting that a drug called alendronate (Fosamax/Merck) may be associated with a significant risk for osteonecrosis of the jaw (ONJ). … READ MORE …

Another serious side effect of bisphosphonates reported

According to HealthDay, a letter to the editor published today in the New England Journal of Medicine reports the very rare occurrence of inflammatory eye disease in patients being treated with bisphosphonates, e.g., alendronate (Fosamax), pamidronate (Aredia), zoledronic acid (Zometa), and others. … READ MORE …