Putting on weight … if you’ve had localized prostate cancer

So even if we don’t want to think or talk about it, most of us are well aware that about 40 percent of all Americans are now obese. In other words, they have a body mass index (BMI) of 30 kg/m2 or higher. … READ MORE …

SABR to oligometastases slows progression via immune response

Stereotactic ablative body radiation (SABR, or sometimes, SBRT) significantly slowed metastatic progression in men with three or fewer metastases (oligometastatic disease). … READ MORE …

Should SBRT be THE preferred treatment for intermediate-risk prostate cancer?

Last year, the American Society of Radiation Oncologists (ASTRO) looked at the available evidence comparing hypofractionated radiotherapy (either 60 Gy in 20 treatments or 70 Gy in 28 treatments) to standard fractionation (78 to 82 Gy in 40 to 44 treatments), and found it was at least as good in terms of oncological outcomes and toxicity. … READ MORE …

SBRT: the optimal dose

While excellent outcomes of stereotactic body radiation therapy (SBRT) have been reported since it was first used to treat prostate cancer in 2003, the delivered doses have ranged from 35 Gy in five treatments to 40 Gy in five treatments. … READ MORE …

SBRT has excellent outcomes for intermediate-risk patients

Stereotactic body radiation therapy or SBRT (sometimes referred to as SABR or SHARP or CyberKnife) has had excellent 7-year outcomes in an update of the consortium study, including data from 10 single-institution trials and two multi-institutional trials. … READ MORE …

SBRT has equivalent toxicity with 5 treatments and 12 treatments: an update

We first reported data from the results of the RTOG 0938 trial in January 2016 when they were presented at the Genitourinary Cancers Symposium in that year. These results have now been formally published, and there are some changes to the data on publication, so Allen Edel has provided an update. … READ MORE …

First randomized clinical trial of SBRT reports primary outcome

In the first trial ever to randomly assign patients to extreme hypofractionation, primary radiation therapy delivered in just seven treatments had the same effectiveness and safety as 39 treatments. … READ MORE …

Salvage SBRT after radical prostatectomy

The University of California, Los Angeles (UCLA) has announced a new clinical trial using stereotactic body radiation therapy (SBRT) for treatment of recurrent prostate cancer after failure of initial prostatectomy. … READ MORE …

Record 10-year SBRT study among low-risk patients

Alan Katz has now published the study with the longest-running follow-up of any study of external beam radiation therapy for prostate cancer among low-risk patients, in this case using SBRT. … READ MORE …

First US randomized clinical trial of oligometastasis-directed SBRT

In a recent commentary (see this link), we saw that some clinicians are making unsubstantiated claims of cancer control from treatment of oligometastases (less than 5 detected metastases). … READ MORE …

Life, behavior, and prostate cancer risk: should you be shedding a few pounds?

The capacity of the average male human to do things that are probably not very good for his health (and to not do things that probably would be good for his health) is considerable. At the most basic level, for example, most of us here in the US don’t eat very wisely and don’t take anything like enough exercise. … READ MORE …

Safety limits of SBRT dose escalation

In a recent commentary, we saw that the lack of a standard of care for stereotactic body radiation therapy (SBRT) dose escalation may put patients at risk when dose limits are pushed beyond what is customarily considered effective and safe. … READ MORE …

SBRT boost radiation therapy in intermediate- and high-risk prostate cancer

Recently we have seen evidence of improved cancer control in high-risk patients treated with external beam radiotherapy with a brachytherapy boost to the prostate. This has been demonstrated with both HDR brachytherapy boost and with LDR brachytherapy boost. … READ MORE …

Salvage SBRT for local recurrence after first-line (primary) radiation therapy

This is the second part of a two-part commentary. In the first part, we looked at studies that identified the site of failure after primary radiation treatment, … READ MORE …

Nine-year outcomes after treatment with SBRT

Katz and Kang will present their 9-year outcomes on 515 patients treated by stereotactic body radiation therapy (SBRT) at the Genitourinary Cancers Symposium tomorrow … READ MORE …