Is once ever enough (in prostate radiation therapy)?

When Jeff Demanes at the California Endocurietherapy Center, then in Oakland, CA, started doing high-dose-rate brachytherapy (HDR-BT) as a monotherapy (i.e., without any additional external beam therapy or hormone therapy), he arbitrarily chose a treatment schedule of 42 Gy delivered in six treatments or fractions. … READ MORE …

Brachytherapy alone is enough for favorable intermediate-risk patients

RTOG 0232 was a large clinical trial conducted to determine whether low-dose-rate brachytherapy (LDR-BT) alone was of equal benefit compared to external beam radiation therapy with a brachytherapy boost (EBRT + LDR-BT) in intermediate-risk patients. … READ MORE …

For very high-risk patients, EBRT + BT is superior to surgery or EBRT only

A retrospective analysis of oncological outcomes among modern-era patients with a Gleason score of 9 or 10 demonstrates a clear advantage to a combination of external beam radiation therapy (EBRT) with a brachytherapy (BT) boost to the prostate and short–term androgen deprivation therapy (ADT). … READ MORE …

Salvage low-dose-rate brachytherapy (LDRBT) after primary LDRBT failure

Although focal retreatment of the prostate using LDRBT has been used after failure of external beam radiation, there have been very few reports of salvage LDRBT after an initial treatment with LDRBT failed. … READ MORE …

Is there an optimal treatment schedule for high-dose-rate brachytherapy?

Protocols for high-dose-rate brachytherapy (HDR-BT) monotherapy vary. In recent years, practitioners have adopted various schedules for patient and physician convenience. … READ MORE …

High-dose EBRT, very high-dose EBRT, or brachy boost therapy – which is best for intermediate- and high-risk patients?

At last week’s Genitourinary Cancers Symposium, Amini et al. presented the results of a data analysis that addresses the question of which kind of high-dose radiation therapy has the best cancer control rates … READ MORE …

Reduction in prostate size prior to permanent seed prostate brachytherapy

Data from a randomized clinical trial have shown that there is more than one way to reduce the size of a man’s prostate (if such cytoreduction is needed) prior to treatment with permanent, radioactive pellets (permanent, low-dose brachytherapy) for localized prostate cancer. … READ MORE …