A clinical research team from the Mayo Clinic (Routman et al.) has reported 10-year oncological results on 974 consecutive low- and intermediate-risk patients treated with low-dose-rate brachytherapy monotherapy (using iodine-125 seeds) from 1998 to 2013. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: brachytherapy, intermediate, low, low-dose-rate, monotherapy, outcome, risk, seeds | 3 Comments »
A group of researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) reported in 2014 (see this link) on the outcomes of 42 patients with radio-recurrent prostate cancer treated with salvage high-dose-rate brachytherapy (sHDR-BT). The results were quite good — … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: brachytherapy, high-dose-rate, low-dose-rate, radiation, salvage, SBRT, stereotactic | Leave a comment »
The ASCENDE-RT trial showed that oncological outcomes were improved among both intermediate-risk and high-risk men who were treated with external beam radiation (EBRT) and a brachytherapy boost (LDR-BT) to the prostate and adjuvant androgen deprivation therapy (ADT) (see this link). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: boost, brachytherapy, effectiveness, risk, safety, Treatment, type | Leave a comment »
The publication of the ASCENDE-RT clinical trial (discussed here) has led to a revision in the brachytherapy guidelines (available here) issued jointly by the American Society of Clinical Oncology (ASCO) and Cancer Care Ontario (CCO). The guidelines are for patients who choose radical therapy rather than active surveillance. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ASCO, brachytherapy, CCO, guideline, risk, Treatment | 1 Comment »
Several randomized clinical trials have established the superior oncological outcomes of the combination of external beam radiotherapy with a high-dose-rate brachytherapy boost (see this link). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: boost, brachytherapy, high, intermediate, progression-free, risk, survival | 1 Comment »
When Jeff Demanes at the California Endocurietherapy Center, then in Oakland, CA, started doing high-dose-rate brachytherapy (HDR-BT) as a monotherapy (i.e., without any additional external beam therapy or hormone therapy), he arbitrarily chose a treatment schedule of 42 Gy delivered in six treatments or fractions. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: brachytherapy, efficacy, fractions, risk, side effects | 4 Comments »
RTOG 0232 was a large clinical trial conducted to determine whether low-dose-rate brachytherapy (LDR-BT) alone was of equal benefit compared to external beam radiation therapy with a brachytherapy boost (EBRT + LDR-BT) in intermediate-risk patients. … READ MORE …
Filed under: Diagnosis, Risk, Treatment | Tagged: beam, brachytherapy, external, low-dose-rate, outcome, radiation | 1 Comment »
A retrospective analysis of oncological outcomes among modern-era patients with a Gleason score of 9 or 10 demonstrates a clear advantage to a combination of external beam radiation therapy (EBRT) with a brachytherapy (BT) boost to the prostate and short–term androgen deprivation therapy (ADT). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Treatment, Uncategorized | Tagged: "high risk", ADT, boost, brachytherapy, comparison, outcome, radiation, surgery | 12 Comments »
Although focal retreatment of the prostate using LDRBT has been used after failure of external beam radiation, there have been very few reports of salvage LDRBT after an initial treatment with LDRBT failed. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: brachytherapy, LDRBT, salvage | Leave a comment »
Protocols for high-dose-rate brachytherapy (HDR-BT) monotherapy vary. In recent years, practitioners have adopted various schedules for patient and physician convenience. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: brachytherapy, dose, HDR, high-dose-rate, outcome, schedule | 2 Comments »
At last week’s Genitourinary Cancers Symposium, Amini et al. presented the results of a data analysis that addresses the question of which kind of high-dose radiation therapy has the best cancer control rates … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: boost, brachytherapy, high-dose, radiation, therapy, very high-dose | 2 Comments »
Data from a randomized clinical trial have shown that there is more than one way to reduce the size of a man’s prostate (if such cytoreduction is needed) prior to treatment with permanent, radioactive pellets (permanent, low-dose brachytherapy) for localized prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Treatment | Tagged: bicalutamide, brachytherapy, cytoreduction, dutasteride, randomized, trial | 6 Comments »
The ASCENDE-RT randomized clinical trial demonstrated that the combination of external beam radiation therapy with a brachytherapy boost (EBRT + BT) significantly reduced biochemical progression-free survival. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: boost, brachytherapy, BT, EBRT, external beam, high, intermediate, mortality, outcome, radiation, risk | 3 Comments »
When the pathology report indicates that prostatectomy alone has been insufficient to control locally advanced prostate cancer, we often turn to adjuvant radiation. However, there is a delay of 3 to 6 months before such adjuvant radiation can be given to allow tissues to heal, but that may allow the cancer to metastasize. … READ MORE …
Filed under: Management, Treatment | Tagged: adjuvant, brachytherapy, intra-operative, radiation | 1 Comment »
The chances that we will ever see a large, randomized, comparative trial of high-intensity focused ultrasound (HIFU) and low-dose-rate (LDR) brachytherapy in the treatment of localized prostate cancer are near to zero. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: brachytherapy, focused, HIFU, high-intensity, LDR, low-dose-rate, outcome, ultrasound | 11 Comments »
THE "NEW" PROSTATE CANCER INFOLINK 