BRCA1/2, prostate cancer, and the Angelina Jolie effect

According to an article in The Sunday Times in the UK over the weekend, a well-known surgeon in the UK is claiming to have carried out “the first” radical prostatectomy on a man with no other indicator for treatment except a BRCA2 mutation and a significant family history of breast and prostate cancer. … READ MORE …

Olaparib shows activity in advanced, BRCA1/2-positive prostate cancer

Apparently a drug known as olaparib (a so-called poly-ADP ribose polymerase or PARP inhibitor) has shown significant signs of activity against advanced prostate cancer in men who carry the BRCA1 and BRCA2 genes. … READ MORE …

Prostate cancer-specific mortality and diagnosis with BRCA1/2-positive disease

A new study just published on line in the Journal of Clinical Oncology had confirmed that “BRCA1/2 mutations confer a more aggressive [prostate cancer] phenotype with a higher probability of nodal involvement and distant metastasis.” This is not a surprising finding, but it does have real implications for men with a family history of BRCA1/2 mutations. … READ MORE …

BRCA1/2 mutations and risk for aggressive prostate cancer

According to another Reuters report, men who develop prostate cancer and who carry one of three possible hereditary mutations to the so-called breast cancer genes BRCA1 and BRCA2 appear to be at particularly high risk for an aggressive form of the disease. … READ MORE …