Posted on August 7, 2019 by Sitemaster
According to a media release issued jointly yesterday by AstraZeneca and Merck, treatment with the PARP inhibitor olaparib (Lynparza) has demonstrated “positive results from the Phase III PROfound trial … in [a subset of] men with metastatic castration-resistant prostate cancer (mCRPC).” … READ MORE …
Filed under: Drugs in development, Living with Prostate Cancer, Management, Treatment | Tagged: ATM, BRCA1/2, castration-resistant, mCRPC, metastatic, olaparib, PARP | 2 Comments »
Posted on January 10, 2018 by Sitemaster
Data from the ongoing, prospective IMPACT study has shown that PSA velocity is not predictive of risk for a positive prostate cancer biopsy result in men who are carriers of the BRCA2 gene. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: BRCA1/2, gene, hereditary, PSA, risk, status, velocity | 1 Comment »
Posted on March 7, 2017 by Sitemaster
A second PARP inhibitor has recently been approved by the US Food and Drug Administration (FDA) for the treatment of patients with BRCA1/2 mutations and advanced ovarian cancer who have already received two types of chemotherapy. … READ MORE …
Filed under: Drugs in development, Management, Treatment | Tagged: advanced, BRCA1/2, inhibitor, PARP | 3 Comments »
Posted on November 11, 2014 by Sitemaster
It is not entirely surprising to come across a paper suggesting that male carriers of the BRCA1/2 genes are at risk for worse post-treatment outcomes than non-carriers of these genes after standard forms of first-line treatment for prostate cancer. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: BRCA1/2, mutation, outcome, risk, Treatment | 2 Comments »