CADT and IADT in the management of progressive and advanced prostate cancer

The debate over the relative values of continuous (CADT) and intermittent (IADT) forms of androgen deprivation therapy (ADT) in the treatment of advanced forms of prostate cancer has now been ongoing for years. … READ MORE …

New meta-analysis endorses IADT for good responders to initial CADT

A new meta-analysis of data from nine large clinical trials suggests that, “There is fair evidence to recommend use of [intermittent] instead of [continuous androgen deprivation] for the treatment of men with relapsing, locally advanced, or metastatic prostate cancer who achieve a good initial response to androgen deprivation.” … READ MORE …

IADT: the still unanswered questions and choices that must be made

About 18 months ago, at the 2011 Genitourinary Cancer symposium in Orlando, Florida, Klotz et al. presented data from a large trial of intermittent (IADT) versus continuous androgen deprivation therapy (CADT) in the management of men with progressive prostate cancer after prior treatment with first- or second-line radiation therapy. We reported their data at the time. … READ MORE …