Prostate cancer outcomes today vs. outcomes yesteryear

As some of us have long suspected and understood, using data from men treated 20+ years ago as a guide to what would happen if you were treated the same way today is not really a very good idea. … READ MORE …

For very high-risk patients, EBRT + BT is superior to surgery or EBRT only

A retrospective analysis of oncological outcomes among modern-era patients with a Gleason score of 9 or 10 demonstrates a clear advantage to a combination of external beam radiation therapy (EBRT) with a brachytherapy (BT) boost to the prostate and short–term androgen deprivation therapy (ADT). … READ MORE …

5-year outcomes after PBRT at a single, high-volume, PBRT center

We have previously reported on the very good, albeit unremarkable, outcomes of proton beam radiation therapy (PBRT) as administered at the University of Florida Jacksonville. … READ MORE …

Are MRI-targeted biopsies “better” than standard 12-core TRUS-guided biopsies?

We often see recommendations that MRI-guided biopsies may be more accurate that transrectal ultrasound (TRUS)-guided biopsies in the diagnosis of prostate cancer. A new systematic review has attempted to assess the current status of data supporting or refuting this recommendation. … READ MORE …

Short-term (perioperative) outcomes of RALP compared to open surgery in 2008-09

A new study available on line as a full-text article in European Urology has provided a retrospective analysis of the perioperative outcomes of men undergoing radical prostatectomy for localized prostate cancer in a 15-month period between October 2008 and December 2009 at 20 percent of the community hospitals in the USA (including public hospitals and academic medical centers). … READ MORE …

VHA cancer management quality study does NOT include prostate cancer

A new study in the Journal of Clinical Oncology has provided data regarding the survival of men of 65 years and older diagnosed with and treated for selected cancers within the Veterans Health Administration (VHA) system as compared to similar men treated under the fee-for-service Medicare system. This study has received a lot of media coverage. … READ MORE …

Watchful waiting vs. external beam radiation: 15-year data from a randomized trial

According to a report presented today at the annual meeting of the American Society for Radiation Oncology (ASTRO) in Miami Beach, Florida, men with localized prostate cancer who were treated 15 years ago with external beam radiation therapy had no significant survival benefit compared to men followed with watchful waiting. … READ MORE …

How much hypofractionated IMRT is too much for localized prostate cancer?

A report to be presented at the upcoming meeting of the American Society for Radiation Oncology (ASTRO) offers 5-year outcome data from a trial comparing conventional intensity-modulated radiation therapy (IMRT) to the more recently developed hypofractionated IMRT for men with localized prostate cancer. … READ MORE …

A matched, case-control study of EBRT + PBRT vs brachytherapy

It would be all too easy to get the idea — from the title and abstract of a recently published study — that proton beam radiation therapy (PBRT) was more effective than permanent seed brachytherapy in the treatment of men with low- and some intermediate-risk prostate cancers. This would be a very inappropriate conclusion. … READ MORE …

5-year brachytherapy outcomes vs. predicted surgical outcomes

As an adjunct to the 12-year outcome data provided in the immediately preceding report come data from Canada that compare actual 5-year brachytherapy outcome data to predicted 5-year surgical outcome data for the same patients. … READ MORE …

Quality of life after first-line treatment: a prospective, comparative study

Data to be published in the May 2010 issue of the Journal of Urology are going to make a lot of urologists rather less than happy about the implications for the use of radical prostatectomy as first-line treatment for prostate cancer. … READ MORE …

Surgery vs. radiotherapy as first-line treatment: an Italian perspective

An Italian study has reported data from a retrospective analysis of outcomes after radical surgery and external beam radiation therapy (EBRT) + androgen deprivation therapy (ADT) in first-line treatment of two, pre-treatment-defined, concurrently treated, high-risk patient populations, all treated at a single institution between January 2003 and December 2007. … READ MORE …

First-line therapy for localized prostate cancer: outcomes and HRQOL

The decisions patients and their doctors make about which treatment to select as first-line therapy for localized prostate cancer are commonly based on perceptions and expectations about the side effects of these treatments, as well as on the curative potential of the therapy. … READ MORE …