Using MRI-guided biopsies to diagnose prostate cancer with high accuracy

Many prostate cancer patients — and particularly those who don’t like the idea of prostate biopsies — think that if one uses MRI-guided biopsies alone one might only need to have one or two biopsy cores taken to accurately diagnose prostate cancer. … READ MORE …

“Extreme apical sampling” and prostate cancer diagnosis

A new article in the September issue of Prostate addresses the potential benefits of “extreme apical sampling” during the initial biopsies of men at risk for prostate cancer based on such standard parameters as PSA level, positive/negative DRE, and related factors. … READ MORE …

LUGPA reacts to suggestions of excessive prostate biopsies in Health Affairs

Not surprisingly, a major urology organization (the Large Urology Group Practice Association or LUGPA) has aggressively disputed the findings recently published by Mitchell in Health Affairs regarding the numbers of prostate biopsies conducted by urology groups with in-house pathology laboratories (see earlier commentary). … READ MORE …

PPC as a key element of clinical stage instead of T stage in localized prostate cancer?

In recent years it has become increasingly widely accepted that clinical stage is of dubious value as a prognostic factor in determining prostate cancer risk, particularly as regards the sub-stages of clinical stage T2 (i.e., T2a, T2b, and T2c) in men with localized prostate cancer. … READ MORE …

How many biopsy cores is the “right” number? (revised and revisited)

The current report offers a revised and updated commentary on the paper by Abd et al., first referred to yesterday on this blog. We have now had the opportunity to read the entire paper. While it does not change the general tenor of our prior comments, it is useful to make sure one has all relevant information on a topic this important. … READ MORE …

How many biopsy cores is the “right” number?

Back in the 1990s, it became customary to carry out prostate cancer biopsies under transrectal ultrasound (TRUS) guidance using the so-called “sextant” approach, under which six preplanned biopsy cores were taken from each of six specific areas of the prostate. … READ MORE …

Prostate cancer news reports: Sunday, November 8, 2009

This weekend’s news report includes items on:

  • Numbers of biopsy cores and accuracy of diagnosis for focal therapy
  • Early data from the Prostate Cancer Research International: Active Surveillance (PRIAS) study
  • Ultrasensitive PSA testing and risk of progression following radical prostatectomy … READ MORE …