Moving targets and the interpretation of “new” medical “knowledge”

In this week’s New England Journal of Medicine (NEJM), there is an interesting article entitled, “Contingent knowledge and looping effects — a 66-year-old man with PSA-detected prostate cancer and regrets”. … READ MORE …

The Metastatic Prostate Cancer Project: an update

In May 2017 we first let you know about the start-up of the Metastatic Prostate Cancer Project, which was subsequently launched in January 2018. Prostate Cancer International is one of the founding partners — along with the Broad Institute and others — in the development and evolution of this project. … READ MORE …

Can MRI data improve decision-making about the need for a biopsy?

Last week we noted that adding MRI data to the Partin tables and to the Kattan/MSKCC nomograms did not seem to improve the accuracy of prognosis of outcomes after radical prostatectomy. … READ MORE …

Statins and the treatment of mCRPC with chemotherapy

A report on the UroToday web site has addressed a presentation given this week at the ESMO 2018 Congress in Munich, Germany, that is relevant to the potential value of taking a statin while you are being treated for very late stage prostate cancer. … READ MORE …

Your genetics can accurately predict your age-related prostate cancer risk

Data from a new study reported in the British Medical Journal discusses a “polygenic hazard score” that can potentially be used to guide screening for aggressive prostate cancer (but only in men of European ancestry at this time). … READ MORE …

Astrology and the interpretation of data from clinical trials

Over the weekend, an  interesting article on clinical trials appeared (somewhat unexpectedly) in the New York Times color supplement. … READ MORE …

Some thoughts on the president’s cancer “moon shot”

It has been a couple of weeks now since Vice President Biden started work on the cancer “moon shot” initiative that President Obama announced during the State of the Union speech to Congress on January 12. … READ MORE …

SBRT registries (and the interpretation of registry-based data)

Patient registries are potentially a rich source of information with which to evaluate outcomes. They often include patient characteristics, details of the therapies they received, and outcomes tracked over time. They also provide full population data of all patients treated at participating centers, and can provide very large amounts of data over time. … READ MORE …

Fallout from elimination of PSA data from the SEER database

On April 29 this year, the National Cancer Institute (NCI) announced a decision to eliminate all PSA data from their current data files because of apparent inaccuracies in the ways that such data had been accumulated over time and administered. The full ramifications of this are — as yet — unclear. … READ MORE …

US national prostate cancer registry coming to life soon

At the annual meeting of the American Urological Association (AUA) this morning, Dr. Matt Cooperberg reported that a total of 450 US-based urologists had now signed up to contribute data on their prostate cancer patients to the AQUA Registry. … READ MORE …

Payers tell PBRT centers that they need better data to justify high prices

According to media reports this morning, a number of payer organizations in the USA are initiating new policies regarding the coverage of proton beam radiation therapy (PBRT) for the treatment of localized prostate cancer. … READ MORE …

ASCO’s new CancerLinQ initiative

As we move near to the annual meeting of the American Society of Clinical Oncology (ASCO) — which will start at the end of May in Chicago — ASCO has been making a lot of noise about its prototype CancerLinQ™ network. Just how valuable this will be for the future management of prostate cancer will take a while to work out. … READ MORE …

ARN-509 posts Phase II data in CRPC and mCRPC at ESMO

There has clearly been a good deal of interest in the data on ARN-509 reported at the recent meeting of the European Society of Medical Oncology (ESMO) … at least from the investment community. … READ MORE …

Something that’s “uncomfortable for doctors”

There’s an interesting opinion piece on the Medscape web site today by Professor Eric Topol of the Scripps Translational Science Institute in La Jolla, California. His subject is “Consumer-driven healthcare makes docs uncomfortable.” … READ MORE …

A sad manipulation of data to support a point of view

Dr. William Catalona has long been one of the strongest advocates of prostate cancer screening. He has been a key individual in the development and promotion of PSA testing for some 20 years, and he believes passionately that prostate cancer screening saves lives. We respect his beliefs and his right to express those beliefs. … READ MORE …