Alzheimer’s, dementia, and androgen deprivation therapy (again)

A new study has concluded that added risk for Alzheimer’s disease and dementia among Medicare patients with prostate cancer who were treated with androgen deprivation therapy (ADT) was minimal in men treated between 2001 and 2014. … READ MORE …

ADT and cardiovascular side effects — redux

A few days ago we commented briefly on a paper by Haque et al. on the risk for cardiovascular complications and side effects of ADT in men initially diagnosed with localized prostate cancer and supposedly managed, initially, on active surveillance. … READ MORE …

ADT and risk for cardiovascular complications of therapy

Not so long ago, we addressed the question of whether first-line androgen deprivation therapy (ADT) was really an appropriate form of care for any man with localized prostate cancer. … READ MORE …

The TOAD trial: follow-up data on quality of life

Some 15 months ago, we reported the initial, primary results of the TOAD trial, which showed an overall survival benefit for immediate as opposed to delayed initiation of androgen deprivation therapy (ADT) in non-metastatic patients considered to be inappropriate for curative therapy. … READ MORE …

Primary ADT in treatment of elderly men with organ-confined prostate cancer

One really has to wonder whether we are still treating elderly men, initially diagnosed with organ-confined prostate cancer, with first-line or “primary” androgen deprivation therapy ADT)! And if we are, why on Earth is that? … READ MORE …

“How are you feeling?” can be an important question for men on ADT

At the upcoming meeting of the American Society for Clincial Oncology (ASCO) meeting in Chicago, Dr. Alicia Morgans of Vanderbilt University will be speaking about the physical and cognitive effects of systemic therapy in older men with prostate cancer. … READ MORE …

Might prostate cancer be a sleep deprivation-related disorder?

According to a report on a presentation given yesterday at an ongoing meeting in Washington, DC, “Adequate sleep isn’t a luxury; it’s essential. And for men, it might even mean the difference between life and death”. … READ MORE …