Understanding “cell-free DNA analysis” in cancer diagnosis and management

We have probably all heard terms like “liquid biopsy” and “genetic screening” and “cell-free” DNA analysis over the past few years. These are all terms related to the use of genetic and genomic information to “personalize” cancer diagnosis and its management. And they are potentially a huge big deal. But, … READ MORE …

Is shear wave elastography the shear wave of the future?

Just this morning, the University of Dundee issued a media release that included the following statement:

an ultrasound process called shear wave elastography (SWE) has been shown to offer much greater accuracy and reliability in diagnosis of prostate cancer, while being a non-invasive and cheaper method than those currently used.

… READ MORE …

PET/MRI scanning in pre-surgical staging of high-risk prostate cancer patients

A small, Norwegian, Phase II clinical trial has explored the potential diagnostic value of [18F]fluciclovine PET/MRI scans of the pelvic lymph nodes in staging for patients with high-risk prostate cancer. … READ MORE …

Potential new imaging agent in diagnosis, monitoring of prostate cancer

About 19 months ago we reported that a company called Progenics Pharmaceuticals had acquired all rights to a small, radiolabeled molecule known as [99mTc]MIP-1404, and that an international, multi-center Phase II trial was  investigating the clinical activity of [99mTc]MIP-1404 as a prostate cancer imaging agent. … READ MORE …

New NCCN guidelines on prostate cancer are not an all-around success!

Alas, the latest revisions to the National Comprehensive Cancer Network (NCCN) guidelines on early detection of prostate cancer seem to have instigated more furore than they have clarity (although the original premise behind them may have been well intentioned). … READ MORE …

Prostate Cancer Roundtable endorses statement on early detection in men at high risk

The Prostate Cancer Roundtable has endorsed a statement developed by the Prostate Health Education Network (PHEN) on the role of PSA testing in the early detection of prostate cancer among men acknowledged to be at elevated risk. … READ MORE …

GE heads up $1 billion cancer detection and treatment plan

If you have a really innovative idea that might impact the diagnosis and treatment of prostate cancer, now’s the time to get your proposal in to GE and its venture capital partners. … READ MORE …

Better ultrasound technology in diagnosis … is it time for change?

For many years a relatively small group of specialists have argued that “enhanced” types of transrectal ultrasound technology (most specifically inclusive of color Döppler ultrasound) have a greater ability to identify possible signs of prostate cancer than traditional “gray-scale” ultrasound. … READ MORE …

As Us TOO International turns 20

In early 1990, Dr. Gerry Chodak — a well-known Chicago-based urologist and then professor of urology at The University of Chicago — wrote a letter to his prostate cancer patients. He said that some of them were interested in starting a prostate cancer support group. From such small beginnings … … READ MORE …

The Göteborg prostate cancer screening trial — now that we’ve read the paper

On Thursday we provided an initial summary of media-reported data from the paper just published by Hugosson et al. in Lancet Oncology. Following is a carefully considered analysis after receipt and study of a copy of the full paper and additional information. … READ MORE …

Detection of local prostate cancer recurrence after EBRT

Data from a small study at the University of California at San Francisco suggest that magnetic resonance (MR) spectroscopic imaging is better than  T2-weighted MR imaging alone for the detection of locally recurrent prostate cancer after definitive external beam radiation therapy (EBRT) as first-line therapy. … READ MORE …

[-2]proPSA and the detection of prostate cancer: new data

We are starting to see a increase in the publication of data about [-2]proPSA — a specific type or isoform of free PSA — and its potential relevance in the detection and diagnosis of prostate cancer. … READ MORE …

Screening vs. clinical detection: prostate cancer in China

A newly published study has compared the clinical and pathological characteristics of screen-detected and clinically diagnosed prostate cancers in Chinese men. … READ MORE …

New review of biomarkers for prostate cancer detection

Nogueira et al. have just published a new “mini-review” in BJU International that addresses the potential roles of current and “future” biomarkers that may have relevance to prostate cancer detection. … READ MORE …

Prostate cancer news reports: Friday, May 29, 2009

Today’s news reports address issues such as:

  • Pro-PSA (a pecursor molecule to PSA itself)
  • A review of development-stage markers for prostate cancer detection
  • Understanding the pathology report
  • A Phase I trial of high-dose testosterone in men with metatstatic CRPC … READ MORE …