TROG 01.03 RADAR, begun in 2003, was a (partly) randomized clinical trial to help optimize therapy of unfavorable-risk patients. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: ADT, brachy boost, dose, extent, external beam, radiation, therapy, timing | Leave a comment »
Data from a recently published, Canadian, clinical trial of high-dose vitamin D as a method to strengthen bones in healthy adults who do not have osteoporesis have had significant and unexpectedly negative results. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: dose, high, outcome, randomized, trial, vitamin D | 18 Comments »
While excellent outcomes of stereotactic body radiation therapy (SBRT) have been reported since it was first used to treat prostate cancer in 2003, the delivered doses have ranged from 35 Gy in five treatments to 40 Gy in five treatments. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Treatment | Tagged: body, dose, optimal, radiation, SBRT, stereotactic | 6 Comments »
We have known for some time that abiraterone acetate 250 mg, when given with food, appears to have activity that may — in at least some patients — be comparable to the activity of abiraterone acetate 1,000 mg given without food. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: abiraterone, dose, food, Zytiga | 3 Comments »
A large, well-done, confirmed, randomized clinical trial (RCT) is the only evidence that proves that one therapy is better than other. According to current consensus, this is deemed “Level 1a” evidence. But this high level of evidence is seldom available. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: decision-making, dose, outcome, radiation, risk, salvage | 2 Comments »
We have known for some time that taking abiraterone acetate (Zytiga) with food (as opposed to on an empty stomach) might well allow patients to be able to take significantly lower doses of this product and gain the same clinical benefit as is currently known to be beneficial from taking 1,000 mg/day when fasting. … READ MORE …
Filed under: Drugs in development, Living with Prostate Cancer, Management, Treatment | Tagged: abiraterone, dose, food, low, standard, with, without | 5 Comments »
Yesterday, in line with previously reported data, the US Food and Drug Administration (FDA) approved the used of a 20 mg/ml dose of cabazitaxel (Jevtana) in the treatment of men with metastatic, castration-resistant prostate cancer (mCRPC). … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: cabazitaxel, dose, Jevtana, lower, mCRPC | Leave a comment »
Is there an optimum treatment dose for sterotactic body radiation therapy (SBRT)? … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: dose, effectiveness, escalation, SABR, safety, SBRT | Leave a comment »
In the late 1990s and early 2000s, the advent of more accurate linear accelerators (LINACs) and image-guidance technology for delivering therapeutic X-rays to the prostate in the treatment of prostate cancer changed the dose that could be safely given. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: dose, radiation, risk, salvage, therapy | Leave a comment »
Recently, we commented on a couple of small studies where radiation re-treatment was used effectively and with acceptable toxicity. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: dose, excessive, radiation, salvage | 2 Comments »
In a recent commentary, we saw that the lack of a standard of care for stereotactic body radiation therapy (SBRT) dose escalation may put patients at risk when dose limits are pushed beyond what is customarily considered effective and safe. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: body, dose, escalation, outcome, radiation, SBRT, stereotactic, toxicity | Leave a comment »
Protocols for high-dose-rate brachytherapy (HDR-BT) monotherapy vary. In recent years, practitioners have adopted various schedules for patient and physician convenience. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: brachytherapy, dose, HDR, high-dose-rate, outcome, schedule | 2 Comments »
Zaorsky et al. conducted a meta-analysis of 12 randomized clinical trials covering data on 6,884 patients treated with external beam radiation at various dose levels. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: dose, level, outcome, radiation, survival, type | Leave a comment »
As discussed in a previous article, there is a seeming discrepancy between the findings of Kalbasi et al. and RTOG 0126, at least for intermediate-risk patients. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: dose, escalation, radiation, risk | Leave a comment »
A group of Italian clinicians and researchers have reported that low-dose abiraterone acetate along with very low-dose prednisone appears to be both effective and safe in the treatment of elderly patients between 85 and 93 years of age with castration-resistant prostate cancer (CRPC). … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: abiraterone, dose, elderly, food, prednisone | 9 Comments »
THE "NEW" PROSTATE CANCER INFOLINK 