For very high-risk patients, EBRT + BT is superior to surgery or EBRT only (redux)

In August last year, Kishan et al. showed a preliminary analysis of oncological outcomes among patients diagnosed with Gleason score 9 and 10 and treated with brachy boost therapy (EBRT + BT), external beam radiation therapy alone (EBRT), or surgery (see this link). … READ MORE …

EBRT works better with ADT for intermediate- and high-risk prostate cancer

The EORTC trial 22991 was designed and implemented to compare external beam radiation therapy (EBRT) + short-term androgen deprivation therapy (ADT) to EBRT alone as first-line therapy in patients with intermediate- and high-risk prostate cancer. … READ MORE …

Brachytherapy boost may lower mortality rate in high-risk patients

The ASCENDE-RT randomized clinical trial demonstrated that the combination of external beam radiation therapy with a brachytherapy boost (EBRT + BT) significantly reduced biochemical progression-free survival. … READ MORE …

Low dose rate brachytherapy monotherapy across risk groups

New registry data from the Cleveland Clinic shows good oncological control with low dose rate brachytherapy (LDRBT) monotherapy, at least for low-risk and low  intermediate-risk groups. This is the first time I’ve seen LDRBT monotherapy data for higher-risk groups. … READ MORE …

Is combination EBRT + LDR-BT worth the risk for most patients?

Long-term data from the Radiaton Treatment Oncology Group (RTOG) 00-19 Phase II trial of external beam radiation therapy (EBRT) + low-dose-rate permanent implant brachytherapy (LDR-BT) has suggested that this type of radiation treatment is probably no more effective than either EBRT or LDR-BT alone … but does have a greater risk for long-term side effects. … READ MORE …

The management of recurrent prostate cancer after first-line therapy

Traditionally, men with prostate cancer who had recurrent disease after first-line surgery or first-line radiation therapy had a limited number of treatment options, but we are now seeing a significant expansion in the range of options available (although limited data are as yet available to support the effectiveness of nearly all these options). … READ MORE …

EBRT + total (combined) ADT in treatment of high-risk, localized and locally advanced prostate cancer

The big news today is the publication, in The Lancet, of the interim results of the NCIC CTG PR.3/MRC UK PR07 trial, originally presented by Warde et al. at the annual meeting of the American Society for Clinical Oncology in June 2010 and then by Mason et al. at the annual meeting of the American Society for Radiation Oncology (ASTRO) that September. … READ MORE …