A matched, case-control study of EBRT + PBRT vs brachytherapy

It would be all too easy to get the idea — from the title and abstract of a recently published study — that proton beam radiation therapy (PBRT) was more effective than permanent seed brachytherapy in the treatment of men with low- and some intermediate-risk prostate cancers. This would be a very inappropriate conclusion. … READ MORE …

EBRT as salvage therapy for refractory or progressive prostate cancer post-HIFU

An early release paper in the Canadian Urological Association Journal offers information on a series of patients treated with external beam radiation therapy (EBRT) as salvage therapy after biochemical progression following high-intensity focused ultrasound (HIFU) as their first-line treatment. … READ MORE …

Statin therapy seems to improve outcomes after radiation therapy for high-risk patients

According to data just published in the March issue of the International Journal of Radiation Oncology•Biology•Physics, patients diagnosed with high-risk prostate cancer who take statins while receiving radiation therapy have a better prognosis than patients treated with radiotherapy who don’t take statins. … READ MORE …

Neoadjuvant hormone therapy for patients undergoing first-line radiation therapy

The Irish Clinical Oncology Research Group trial 97-01 was a randomized clinical trial designed to compare the long-term outcomes of patients treated with either 4 months or 8 months of hormonal therapy given before external beam radiotherapy for localized prostate cancer. … READ MORE …

RP vs. EBRT vs. ADT as first-line therapy for localized prostate cancer

Earlier this year we reported on a paper by Zelefsky et al. suggesting lower levels of prostate cancer-specific morbidity and mortality after surgery than after radiation therapy. Now there’s similar data from the CaPSURE registry. … READ MORE …

Does concurrent statin therapy help men who have EBRT for localized disease?

We know that statin therapy appears to lower risk for prostate cancer and to increase the overall survival of men diagnosed with prostate cancer. However, what we don’t know (yet) is whether statin therapy during and after specific types of treatment has prostate cancer-specific outcome benefits. … READ MORE …

Prostate cancer patients on statins have better outcomes after radiotherapy

There is an increasing range of evidence to suggest that men who are on long-term statin therapy (with drugs like simvastatin, atorvastatin/Lipitor, or rosuvastatin/Crestor) are at lower risk for prostate cancer and do better than average in terms of treatment outcome if they are diagnosed with prostate cancer. … READ MORE …

Chronic fatigue after first-line therapy for localized prostate cancer

There are few good data on the occurrence of chronic fatigue after first-line treatment of localized prostate cancer. … READ MORE …

Decline in sexual function after radiation therapy for prostate cancer

A newly published report suggests that sexual function does indeed decline after external beam radiation therapy (EBRT) for prostate cancer — but only over the first 2 years post-treatment. … READ MORE …

Prostate cancer news reports: Wednesday, January 20, 2010

In today’s news reports we comment on three different articles dealing with radiotherapy in first-line treatment for localized prostate cancer:

  • Iodine-125-based brachytherapy without adjuvant hormone therapy or EBRT in younger males
  • Comparative outcomes of brachytherapy patients of 60 and younger and > 60 years of age
  • Radiation toxicities after EBRT in men who have had a prior TURP … READ MORE …

Hormones + brachytherapy + EBRT: more than we need?

A paper in press in the Journal of Urology has suggested that, for patients with intermediate-risk prostate cancer who elect treatment with a combination of standard (low dose) brachytherapy and external beam radiation therapy (EBRT), the addition of hormone therapy adds little in terms of clinical benefit. … READ MORE …

Long-term follow-up of patients needing post-RP salvage radiation

A long-term study from the Mayo Clinic reports a low incidence of complications (other than erectile dysfunction) following salvage radiotherapy for men with prostate cancer recurrence after an initial radical prostatectomy. … READ MORE …

QOL after cryotherapy vs. EBRT

Earlier this year we reported the initial results of a truly randomized Canadian trial of cryotherapy vs. external beam radiation therapy (EBRT) for the treatment of localized prostate cancer. The same group of authors have now reported follow-up data on quality of life. … READ MORE …

Prostate cancer news reports: Tuesday, July 21, 2009

In today’s news reports we comment on studies dealing with:

  • PSA level, body mass index, risk, and outcomes
  • External beam radiotherapy in treatment of Japanese patients
  • An endorectal balloon to prevent anal/rectal side effects of radiation?
  • The optimal period of neoadjuvant hormone therapy prior to radiation therapy … READ MORE …

Prostate cancer news reports: Saturday, July 18, 2009

In today’s news reports you will find items on:

  • Obesity and PSA levels
  • Outcomes after external beam radiation therapy
  • Mitoxantrone + predisone after taxotere failure … READ MORE …