Intense discussion of the future of focal therapy in prostate cancer

At a 4-hour meeting yesterday afternoon here in New Orleans there was intense discussion of issues related to the future of focal therapy and (potentially) to the approval of new types of device and technologies that might be able to deliver focal therapy. … READ MORE …

Eligibility criteria for active surveillance among men with low-risk prostate cancer

As regular readers of this blog will be aware, the urology group at Johns Hopkins in Baltimore has, for the past several years, had one of the most restrictive sets of criteria for eligibility for active surveillance as an appropriate method for the management of men initially diagnosed with low- and very low-risk prostate cancer. … READ MORE …

Should all low-risk prostate cancer patients be re-biopsied prior to implementation of active surveillance?

Centers apply a variety of inclusion criteria in evaluating the eligibility of patients for management using active surveillance (AS) protocols. The applicability of an immediate, transrectal ultrasound (TRUS)-guided re-biopsy is recommended by a number of centers, but there is no consensus about the need for re-biopsy at this time. … READ MORE …

Eligibility of CRPC patients for randomized clinical trials

Guidelines suggest that the optimal management of patients with castration-resistant prostate cancer (CRPC) — also known as hormone-refractory prostate cancer or HRPC — is participation in a randomized clinical trial. But encouraging community-based clinicians to enroll their patients in clinical trials has long been problematic. … READ MORE …

Further defining the potential for focal therapy

A study from investigators at M. D. Anderson Cancer Center has attempted to assess the likelihood of total eradication of prostate cancer in men with prostate cancer that is found in only one lobe of the prostate and who would  qualify for subtotal prostate ablation with controlled thermal energy using such techniques as cryoablation or high-intensity focused ultrasound. … READ MORE …

Who is an appropriate candidate for focal therapy, and how do we know?

Yesterday we posted a commentary on a review by Marberger et al. that addressed the potential of certain techniques as focal therapies for localized forms of prostate cancer. … READ MORE …