New data suggest that salvage HIFU after EBRT is “a high-risk procedure”

A new article reports data from two centers on experience with whole-gland high-intensity focused ultrasound (HIFU) salvage therapy for local recurrence following external beam radiation therapy (EBRT). .. READ MORE …

EBRT + total (combined) ADT in treatment of high-risk, localized and locally advanced prostate cancer

The big news today is the publication, in The Lancet, of the interim results of the NCIC CTG PR.3/MRC UK PR07 trial, originally presented by Warde et al. at the annual meeting of the American Society for Clinical Oncology in June 2010 and then by Mason et al. at the annual meeting of the American Society for Radiation Oncology (ASTRO) that September. … READ MORE …

Predicting sexual function after first-line treatment for prostate cancer

A newly published report in the Journal of the American Medical Association provides data (from two large cohorts of patients) on the quality of sexual function among men undergoing first-line treatment for localized prostate cancer. … READ MORE …

New ACR Appropriateness Criteria® for locally advanced (high risk) prostate cancer

For readers who are “into” the technical details, the American College of Radiology (ACR) has just updated the ACR Appropriateness Criteria® for the use of radiation therapy in the management of locally advanced (high risk) prostate cancer. … READ MORE …

All the different types of external beam radiation therapy for prostate cancer: a good introduction

Over the past 20 years there has been an explosion in the different ways that we use varied types of external beam radiation therapy for the treatment of localized and locally advanced forms of prostate cancer. Where is the newly diagnosed patient able to find a good, basic introduction? … READ MORE …

Health-related QOL after salvage HIFU for recurrent, localized prostate cancer

Men with locally recurrent prostate cancer after first-line external beam radiation therapy (EBRT) have historically had three options for second-line treatment: salvage radical prostatectomy, salvage cryoablation, and salvage brachytherapy. … READ MORE …

EBRT as salvage therapy for refractory or progressive prostate cancer post-HIFU

An early release paper in the Canadian Urological Association Journal offers information on a series of patients treated with external beam radiation therapy (EBRT) as salvage therapy after biochemical progression following high-intensity focused ultrasound (HIFU) as their first-line treatment. … READ MORE …

“The pros and and cons of prostate cancer treatment options”

The Johns Hopkins Health Alerts yesterday issued a new summary of the up- and the downsides of the four “standard” treatments for localized prostate cancer: active surveillance, radical surgery, external beam radiation therapy, and brachytherapy (with permanent seed implantation). … READ MORE …

More from the European comparative effectiveness research front

Apparently the German health system is to initiate a large trial to investigate the comparative effectiveness of four different treatments for men initially diagnosed with low-risk prostate cancer, starting this year. … READ MORE …

10-year follow-up of brachytherapy “plus” in high-risk, localized prostate cancer

The stream of information about long-term outcomes after brachytherapy continues with an article on 10-year outcomes of high-risk patients treated with brachytherapy, adjuvant external beam radiation, and adjuvant androgen deprivation (ADT). … READ MORE …

Neoadjuvant hormone therapy for patients undergoing first-line radiation therapy

The Irish Clinical Oncology Research Group trial 97-01 was a randomized clinical trial designed to compare the long-term outcomes of patients treated with either 4 months or 8 months of hormonal therapy given before external beam radiotherapy for localized prostate cancer. … READ MORE …

RP vs. EBRT vs. ADT as first-line therapy for localized prostate cancer

Earlier this year we reported on a paper by Zelefsky et al. suggesting lower levels of prostate cancer-specific morbidity and mortality after surgery than after radiation therapy. Now there’s similar data from the CaPSURE registry. … READ MORE …

Does concurrent statin therapy help men who have EBRT for localized disease?

We know that statin therapy appears to lower risk for prostate cancer and to increase the overall survival of men diagnosed with prostate cancer. However, what we don’t know (yet) is whether statin therapy during and after specific types of treatment has prostate cancer-specific outcome benefits. … READ MORE …

Prostate cancer patients on statins have better outcomes after radiotherapy

There is an increasing range of evidence to suggest that men who are on long-term statin therapy (with drugs like simvastatin, atorvastatin/Lipitor, or rosuvastatin/Crestor) are at lower risk for prostate cancer and do better than average in terms of treatment outcome if they are diagnosed with prostate cancer. … READ MORE …

Post-treatment mortality of elderly men with high-risk prostate cancer

New data from a series of > 700 elderly patients with high-risk prostate cancer suggests that aggressive combination therapy for such men is associated with a reduced risk for prostate cancer-specific mortality. … READ MORE …