Long-term adjuvant ADT improves results of brachy-boost therapy in unfavorable-risk prostate cancer patients

TROG 01.03 RADAR, begun in 2003, was a (partly) randomized clinical trial to help optimize therapy of unfavorable-risk patients. … READ MORE …

Brachy boost therapy and surgery extend survival about the same in high-risk patients, but brachy boost does more

Two retrospective studies were published in the last week, and they had some similar findings, but some dissimilar things to say about which treatment is best for high-risk prostate cancer. … READ MORE …

EBRT works better with ADT for intermediate- and high-risk prostate cancer

The EORTC trial 22991 was designed and implemented to compare external beam radiation therapy (EBRT) + short-term androgen deprivation therapy (ADT) to EBRT alone as first-line therapy in patients with intermediate- and high-risk prostate cancer. … READ MORE …

Brachytherapy boost may lower mortality rate in high-risk patients

The ASCENDE-RT randomized clinical trial demonstrated that the combination of external beam radiation therapy with a brachytherapy boost (EBRT + BT) significantly reduced biochemical progression-free survival. … READ MORE …

Early data from the ASCENDE-RT trial misleadingly presented

News reports (and apparently a media release) have been suggesting that ‘A prostate cancer treatment using permanently implanted radioactive “seeds” doubles rates of 5-year tumor-free survival compared with conventional high-dose radiotherapy.’ Unfortunately, these reports are somewhat — or perhaps very — misleading. … READ MORE …

EBRT + LDRBT boost provides superior cancer control compared to EBRT alone

Numerous retrospective analyses have suggested that the combination of external beam radiation therapy (EBRT) with a low-dose-rate brachytherapy (LDRBT) boost is highly effective in controlling prostate cancer in unfavorable-risk patients. … READ MORE …

10-year survival data from the RT01 trial of differing doses of 3D-CRT

According to a paper just published in Lancet Oncology today, the 10-year follow-up results of the RT01 trial carried out under the auspices of the British Medical Research Council have shown an overall survival of 71 percent in both arms of this trial of two types of external beam radiation therapy. … READ MORE …

5-year survival of high-risk patients after EBRT + brachytherapy

Long-term data on survival of high-risk patients after treatment with a combination of external beam radiation therapy (EBRT) and brachytherapy (radioactive seed implantation), with or without neoadjuvant and adjuvant androgen deprivation therapy (ADT), are not well established as yet. … READ MORE …

Radiation therapy for localized prostate cancer in men with diabetes mellitus

A new paper recently published on line in Urology (“the Gold Journal”) suggests that men with diabetes who are treated with curative intent for localized prostate cancer using external beam radiation therapy may experience higher than normal risk for late genitourinary complications and adverse effects. … READ MORE …

EBRT + long-term ADT in treatment of men with high-risk, localized prostate cancer

A retrospective analysis has (again, somewhat predictably) shown that adding long-term androgen deprivation therapy (ADT) to dose-escalated radiation therapy improves outcomes of men initially diagnosed with high-risk prostate cancer. … READ MORE …

Is combination EBRT + LDR-BT worth the risk for most patients?

Long-term data from the Radiaton Treatment Oncology Group (RTOG) 00-19 Phase II trial of external beam radiation therapy (EBRT) + low-dose-rate permanent implant brachytherapy (LDR-BT) has suggested that this type of radiation treatment is probably no more effective than either EBRT or LDR-BT alone … but does have a greater risk for long-term side effects. … READ MORE …

Brachytherapy: is it really “better” as a first-line treatment for low- and intermediate-risk prostate cancer?

An analysis of data on treatment of nearly 137,500 men treated for prostate cancer between 1991 and 2007 has suggested that permanent seed brachytherapy may be safer, less costly, and at least as effective as any other widely available form of first-line therapy for men with low- and intermediate-risk prostate cancer. … READ MORE …

Patient satisfaction after first-line treatment for localized prostate cancer (in Germany)

A new article in the journal Anticancer Research suggests that patients had greater satisfaction after modern forms of external beam radiation therapy (EBRT) than after some other standard forms of first-line treatment. Of course the absolute truth of this conclusion may be affected by the details of the study. … READ MORE …