Focal therapy of just the index or primary lesion

A newly published paper in European Urology has provided us with data from one of the earliest, well-documented series of patients undergoing focal therapy of the index lesion from what is known to have been multifocal prostate cancer. … READ MORE …

NanoKnife or irreversible electroporation treatment as a potential focal ablation therapy

Ireversible electroporation (IRE), using the NanoKnife® system, is unique among focal ablation therapies in that it is non-thermal and precise down to the cellular level. … READ MORE …

Approval of some form of Sonacare Medical’s HIFU technology?

Readers may wish to be aware that your sitemaster has been hearing whispers and rumblings that the U.S. Food and Drug Administration is either about to or has just approved some form of Sonacare Medical’s Sonablate high-intensity focal ultrasound (HIFU) techology for treatment of something related to the prostate. … READ MORE …

Second-line treatment for men with radiorecurrent prostate cancer (the FORECAST trial)

An ongoing clinical trial available exclusively in the UK is the so-called FORECAST trial, designed to investigate focal forms of second-line therapy for men with progressive, radiorecurrent prostate cancer after first-line treatment with external beam radiation therapy. … READ MORE …

Intense discussion of the future of focal therapy in prostate cancer

At a 4-hour meeting yesterday afternoon here in New Orleans there was intense discussion of issues related to the future of focal therapy and (potentially) to the approval of new types of device and technologies that might be able to deliver focal therapy. … READ MORE …

Focal cryotherapy in the treatment of localized prostate cancer

A recent article in Expert Review of Anticancer Therapy has assessed the effectiveness and safety of focal cryotherapy in the first- and second-line treatment of localized prostate cancer. … READ MORE …

Expert opinion on criteria for application of focal therapy

The  statements that you will find below represent the “expert opinion” of a multinational group of specialists who have been using focal therapy investigationally in the treatment of men with certain types of prostate cancer in recent years. … READ MORE …

Focal therapy today: upsides and downsides

While there is considerable allure to the theory behind focal therapy (and focal laser therapy or FLA in particular) as a treatment for some men with localized prostate cancer, it is worth understanding that there are good reasons to consider this allure with great caution. … READ MORE …

The value of focal therapy in the treatment of localized prostate cancer

The appropriate use of focal therapy in the treatment of low-risk and perhaps intermediate-risk prostate cancer is a very controversial topic (despite the heavy promotion of this type of treatment by a relatively small number of clinicians). … READ MORE …

Focal therapy: time to step up to the plate (or not)!

An opinion piece in the May 4 issue of the Journal of Clinical Oncology has outlined serious (and not unreasonable)  questions about the long-term viability of focal therapy (of any type) as a method for the treatment of small foci of localized prostate cancer. … READ MORE …

New Phase I/II trial of InSightec’s MRI-guided focal ultrasound therapy

According to a media release issued yesterday by the City of Hope medical center in Los Angeles, they have become the first center in the USA to treat a patient with focused, MRI-guided, ultrasound technology using the InSightec system. … READ MORE …

Focal therapy for organ-confined prostate cancer: an expert overview

For those who are interested in the current state of focal therapy in the management of localized, organ-confined prostate cancer, there is a nice audio overview by Dr. James Eastham of the Memorial Sloan-Kettering Cancer Center on the UroToday web site. … READ MORE …

Early data on targeted focal therapy in treatment of localized prostate cancer

The potential role of targeted focal therapy in the management of localized prostate cancer is yet to be well-defined, so a paper just published on line in the Journal of Urology is of value in helping us to set our expectations. … READ MORE …

Intervew with three leading researchers at the NCI

Many readers may be interested in having a look at the text based on a recent interview carried out with four clinicians who specialize in research into the management of prostate cancer at the National Cancer Institute (NCI) and the NCI Clinical Center in Bethesda, Maryland. … READ MORE …

Focal cryotherapy for localized prostate cancer

A new review article on the use of focal cryotherapy in the treatment of localized prostate cancer has recently been published in the journal Cancer Control. The full text of this article by Nguyen et al. is also available on the Medscape web site. … READ MORE …