Data from a formal Phase I trial of MR-guided, focal laser surgery

A paper on line in the journal Radiology offers some of the earliest, formally published data from a major academic medical center on the clinical use of focal laser ablation in the treatment of low-risk prostate cancer. … READ MORE …

MRI-guided focused ultrasound in focal treatment of low-risk, localized prostate cancer

In October last year, the US Food and Drug Administration approved the ExAblate MRI-guided focused ultrasound technology for the treatment of pain associated with cancer metastasis to bones, which is obviously a potential benefit for men with late stage, metastatic prostate cancer. … READ MORE …

More on the hypothetical potential of focal therapy for prostate cancer

A new article (available in full text) discusses the hypothetical potential of focal therapy as a form of treatment that “bridges the gap” between active surveillance and whole gland surgery or whole gland ablation for men with small amounts of early stage cancer that is entirely confined to their prostates. … READ MORE …

The current state of focal therapy for localized prostate cancer

Many readers may be interested in two expert interviews on the OncologySTAT web site with Dr. Mark Emberton (a member of the Scientific Advisory Board of The “New “Prostate Cancer InfoLink). … READ MORE …

NICE publishes guidance on focal HIFU for the treatment of localized prostate cancer in UK

In the UK, the National Institute for Clinical Excellence (NICE) has just published guidance on the use of focal forms of high-intensity focused ultrasound (HIFU) for the treatment of (low- and intermediate-risk forms of) localized prostate cancer. … READ MORE …

Focal HIFU in men with localized prostate cancer — data from a small, initial, UK trial

A report just published on line in The Lancet Oncology provides data from a study of the use of focally directed (as opposed to whole gland) high-intensity focused ultrasound (HIFU) in the treatment of a small series of men with localized prostate cancer between 2007 and 2010. The data are interesting but follow-up to date is short. … READ MORE …

Focal cryotherapy: an update from the COLD registry

A new paper in BJU International offers an analysis of data on the effectiveness and safety of focal cryotherapy (partial cryoablation of the prostate) as a first-line treatment for localized prostate cancer from the national Cryo On-Line Database (COLD) registry collected between 1997 and 2007. … READ MORE …

Feasibility of focal HIFU: a pilot study with 10-year follow-up data

The potential of high-intensity focused ultrasound (HIFU) as a form of focal therapy for treatment of cancer isolated to a portion of the prostate as opposed to treatment of the entire prostate has been recognized for a considerable period of time. However, limited data are available so far on the outcomes of men treated with focal HIFU. … READ MORE …

Prostate cancer news report: Sunday, January 24, 2010

In this weekend’s prostate cancer news reports, we have addressed recent publications on:

  • A SNP that may be specifically linked to risk for prostate cancer in African Americans
  • The need for extended biopsies in men with larger prostates who are considering focal treatment for prostate cancer
  • A possible association between diabetes, race, obesity, and risk for prostate cancer progression
  • Neoadjuvant hormone therapy, brachytherapy, and all cause mortality in older patients … READ MORE …

The Tuesday news update: March 10, 2009

Today’s news reports include items on:

  • Risk for prostate cancer
  • Patient decisions about sexual functionality and prostate cancer treatment
  • Whole gland and focal cryotherapy
  • Testosterone replacement after prostate cancer therapy

and other items. … READ MORE …

Tuesday’s news and reports: December 16, 2008

There are a number of interesting (if somewhat technical) reports today dealing with the following issues:

  • The size and metabolism of the “normal” prostate and their relationship to age
  • Defining who is potentially appropriate for focal therapy
  • Saw palmetto berry extract as an anti-tumor agent?
  • Is chlormanidone a helpful non-steroidal antiandrogen? … READ MORE …

Is focal cryotherapy appropriate for localized disease?

A review article by Polascik et al. in this month’s issue of Oncology addresses the potential of third-generation cryosurgical technology as a method to treat localized prostate cancer by freezing only targeted areas of the gland as opposed to the entire prostate. … MORE …