Prognosis of patient progression and outcomes on active surveillance

The prostate cancer research team led by Dr. Peter Pinto at the National Cancer Institute has just published some interesting new information on risk for disease progression in men on active surveillance. … READ MORE …

Continuity of care for men initially started on active surveillance

You may have noticed that your sitemaster has become a tad obsessed with the ways in which active surveillance is being carried out at different centers and the potential for standardization of this process in the interests of definable groups of patients. … READ MORE …

Record 10-year SBRT study among low-risk patients

Alan Katz has now published the study with the longest-running follow-up of any study of external beam radiation therapy for prostate cancer among low-risk patients, in this case using SBRT. … READ MORE …

15-year metastasis-free survival in men on active surveillance in The Netherlands

According to new data reported at the annual meeting of the European Association of Urology in London, active surveillance of men diagnosed with low-risk prostate cancer was not associated with an elevated risk for metastatic disease at 15 years of follow-up. … READ MORE …

Another systemic failure of care and about whether anyone cared at all

Sometimes it’s easier to blame the patient than it is to blame the medical system, and so that’s what people often do. But if one is going to blame the patient, then one really ought to have data to back it up. … READ MORE …

How long is long enough? Length of follow-up on clinical trials for primary treatments

Many of us are faced with the difficulty of choosing a primary therapy based on data from clinical trials with follow-up shorter than our life expectancy. How can we know what to expect in 20 or 30 years? … READ MORE …

Re-classification rates on repeat biopsy for men on active surveillance in the Hopkins cohort

So there is an interesting new paper on the ramifications of active surveillance in the forthcoming June issue of the Journal of Urology — based on the extensive data now collected by the Johns Hopkins group through their very conservative active surveillance cohort of > 1,200 men accumulated since 1995. … READ MORE …

Which patients with a PSM post-surgery need early adjuvant therapy?

Could more intensive monitoring of PSA levels in the first few months after a radical prostatectomy help to determine which patients who have a positive surgical margin (PSM) need adjuvant radiation therapy and which don’t? … READ MORE …

30 years follow-up of men with initially untreated, localized prostate cancer

A new article in European Urology offers interesting data on the natural history of localized prostate cancer, based on a cohort of 200+ Swedish patients followed for > 30 years. It is important to note immediately that none of these men was originally diagnosed in the PSA era. They all had some form of symptomatic disease at diagnosis. … READ MORE …

Orgasmic function is not the same as sexual function: what are we really being told?

We are having a hard time with a media release issued yesterday by BJU International in relation to a study just published in that journal by Tewari et al. (Actually, we are having a hard time with the results of the study itself too.) … READ MORE …

Survey suggests high level of long-term side effects after treatment for prostate cancer

According to new data presented at the Frontiers in Cancer Prevention Research meeting ongoing this week in Boston, MA, some 70 percent of prostate cancer patients participating in a survey in Michigan reported long-term, treatment-related, adverse effects after first-line treatment with surgery or radiation therapy. … READ MORE …

PSA monitoring after prostate cancer surgery: how long is long enough?

A paper currently “in press” in the Journal of Urology suggests that annual PSA testing “may be safely discontinued after 10 years for men with a prostatectomy Gleason score 6 or less and/or limited life expectancy.” … READ MORE …

Delayed follow-up care of men with a high PSA found to be common

For any man with a first-time PSA level > 10 ng/ml, there is significant risk for prostate cancer, and early follow-up care — including a repeat PSA test and potentially a biopsy — is probably a priority unless the patient has a life expectancy of 10 years or less. … READ MORE …

Follow-up after finding of “atypia” on initial prostate biopsy

It has long been understood that a finding of “atypia” (atypical small acinar proliferation) on an initial biopsy of the prostate is associated with an increased risk for prostate cancer, and a repeat biopsy is normally recommended for any patient with an initial finding of atypia. … READ MORE …

Evolving “best practices” in the application of active surveillance

A new paper based on the cohort of patients being followed with active surveillance (AS) at Memorial Sloan-Kettering Cancer Center (MSKCC) has added to our understanding of the potentially optimal management of patients on AS. … READ MORE …