Major trial confirms value of zoledronic acid dosed every 3 months in preventing pain, SREs

An interesting paper that we managed to miss at the recent annual meeting of the American Society of Clinical Oncology (ASCO) provided the results of a large, randomized clinical trial of the use of zoledronic acid, carried out by the Cancer and Leukemia Group B cooperative trial group. … READ MORE …

Prostate cancer news reports: January 6, 2010

Recent reports have addressed the following issues related to prostate cancer:

  • How many biopsy cores is the right number?
  • How “open” surgeons have adapted to laparoscopic surgery
  • Hypoxia, the tumor environment, and how it affects treatment
  • Gefitinib + radiation therapy in intermediate- and high-risk prostate cancer
  • Fractures, prostate cancer, and androgen deprivation … READ MORE …

A critical week for denosumab

Tomorrow (Thursday) an advisory committee to the US Food and Drug Administration (FDA) meets to decide whether to recommend approval of Amgen’s new RANK-L inhibitor, denosumab, which offers an entirely new mechanism for the reduction of the risk of fractures and other skeletal related events (SREs) caused by long term hormone therapy (both in patients with breast cancer and those with prostate cancer). … READ MORE …

AUA report and update no. 2: Sunday, April 26, 2009

Two important papers presented this afternoon addressed data on the use of toremifene and denosumab on the bones of men receiving treatment with androgen deprivation therapy (ADT). … READ MORE …