Three articles in the October 12 issue of JAMA Oncology address the fact that a very specific germline mutation to the so-called HSD3B1 gene affects response to standard forms of initial androgen deprivation therapy and related factors. … READ MORE …
Filed under: Diagnosis, Management, Living with Prostate Cancer, Drugs in development, Risk | Tagged: 3βHSD1, ADT, genetic, germline, HSD3B1, profile, response, Treatment | Leave a comment »
A newly published paper in the journal JCO Precision Oncology confirms what many of us may have suspected — that the practical application of somatic tissue testing to clinical decision-making was low prior to 2015 . … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Treatment | Tagged: genetic, genomic, genotyping, immunohistochemistry, medicine, molecular, precision, test | 25 Comments »
A new paper in a new journal argues that all men diagnosed with advanced forms of prostate cancer should now, routinely, be undergoing tumor and germline DNA profiling … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: analysis, genetic, genomic, targeted, testing, therapy | 2 Comments »
A newly published article in the Journal of the National Cancer Institute has suggested that men carrying a particular genetic mutation in the kallikrein 6 gene (KLK-6) have an increased risk for aggressive, clinically significant prostate cancer. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: aggressive, genetic, kallikrein, KLK-6, mutation, risk | 2 Comments »
As regular readers will be well aware, there are now several different tests available that can be used to assess risk for low- and very low-risk forms of prostate cancer at time of diagnosis (as opposed to clinically significant forms that need early treatment). … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment, Uncategorized | Tagged: cost, genetic, genomic, Management, risk, test | 4 Comments »
As we have pointed out regularly over the years, all prostate cancers are by no means the same. And a recently published paper in European Urology makes the inherent diversity in the subtypes of prostate cancer even clearer — even within any one specific patient. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: Diagnosis, genetic, genomic, prognosis, result, test, variation | 16 Comments »
We know that a family history of prostate cancer and the presence of certain genetic/genomic markers are associated with increased risk for prostate cancer in general and for some types of clinically significant prostate cancer in particular. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: counseling, family, genetic, history, PSA, risk, score, testing | 3 Comments »
