Baldness patterns, genetics, and risk for prostate cancer

According to a newly-published study in the Journal of Clinical Oncology, certain types of male baldness are associated with a heightened risk for aggressive forms of prostate cancer (but this finding really needs to be confirmed in other studies). … READ MORE …

Parental diagnosis and familial risk for prostate cancer: an 78-year analysis

A new study in the European Journal of Cancer has confirmed the key importance of heredity (i.e., genetic inheritance) as one of the risks for prostate cancer and two other common forms of cancer (breast and colorectal cancers). … READ MORE …

Prostate cancer in younger men: an important new review

An article in this month’s issue of Nature Reviews: Urology has looked closely at a question of significant relevance to an important subset of our regular readers — Is prostate cancer in some way “different” in younger men? … READ MORE …

Epidemiology, genetics, and risk for (aggressive) prostate cancer

A couple of papers presented in the past few days at meetings of the American Association for Cancer Research (AACR) and the American Society for Human Genetics (ASHG) provide us with interesting (if potentially confusing) information about risk for a diagnosis of prostate cancer. … READ MORE …

Lots more genetic information; practical implications still to come

There is a long (full-text) commentary this week in Nature Genetics about new data just reported by participants in the  large-scale Collaborative Oncological Gene-environment Study (COGS). Some of the data are relevant specifically to risk for prostate cancer. … READ MORE …

Genetics, genomics, targeted therapy, and “personalized” cancer care

If you are still under the illusion that, simply by identifying the precise structure of the deoxyribonucleic acid (DNA) of patients’ cancer cells, we will be able to develop and target drugs that can eliminate specific cancers (or indeed other disorders) in specific individuals, an article by Sharon Begley on the Reuters.com web site should help to disabuse you. … READ MORE …

Another “Holy Grail” being touted for diagnosis of high-risk prostate cancer

Another new test — this time (supposedly) reported on-line in the American Journal of Pathology (and scheduled for publication in the June issue of that journal) — has suggested that monitoring genetic variation may be helpful in predicting risk from specific types of prostate cancer. If one is to believe the report in today’s Pittsburgh Post-Gazette, the new test ‘could represent “the Holy Grail of prostate cancer” by specifying from the start whether aggressive treatment is necessary’ … READ MORE …

New data on the genetics of aggressive prostate cancer, but …

A new paper in the Proceedings of the National Academy of Sciences suggests the existence of a subset of “hypermutated” cell lines in some forms of aggressive prostate cancer. … READ MORE …

UK includes prostate cancer in new “stratified medicine” pilot program

According to a report in the Science section of the Financial Times, “the world’s first nationwide genetic testing programme for cancer patients goes into action in the UK next month, with support from the public, private and charitable ­sectors.” … READ MORE …

Of genetics, diabetes, and prostate cancer risk

We know from a number of older, epidemiologic studies that there seems to be an inverse association between diabetes status and prostate cancer risk. In other words, people with diabetes seem to be less likely to be diagnosed with prostate cancer. … READ MORE …

Expanding understanding about African ancestry and prostate cancer risk

A detailed, new genetic analysis of known prostate cancer susceptibility loci appears to have been able to refine our understanding of genetic factors affecting the risk for prostate cancer among African Americans. … READ MORE …

Can MVP help us to understand the genetics of prostate cancer?

According to an announcement from the Veterans Administration (VA), it intends to roll out a new program called the Million Veterans Program or MVP which will allow pre-approved research teams to access (de-identified) genetic, military exposure, health, and lifestyle information on U.S. veterans together through one single database. … READ MORE …

Genetics, genomics, and improvements in the management of prostate cancer

Over the past few years we have seen a great deal of discussion of this or that new gene or single nucleotide polymorphism (SNP) or other set of genomic data and the potential of such information to improve the diagnosis or the prognosis of prostate cancer. … READ MORE …

An update on hereditary and familial prostate cancers

For those interested in “brushing up” on their understanding of the risks associated with hereditary and familial forms of prostate cancer, we recommend a brief article in the April issue of the AUA News, which summarizes a “state of the art” lecture to be given by the author at the upcoming annual meeting of the American Urological Association. … READ MORE …

114-candidate gene panel can detect nearby prostate cancer in stromal prostate tissue

There has been a lot of media “chatter” over the past 3 days about an article published in the journal Cancer Research. The article suggests that an investigational genetic test can project the presence of prostate cancer in biopsy-based specimens with an average accuracy of 97 percent. … READ MORE …