Posted on February 2, 2017 by Sitemaster
So a relatively new article in Reviews in Urology caught your Sitemaster’s eye this morning — and worried him because it seemed to be communicating a conclusion of questionable accuracy, which we will explore below. And if we have misinterpreted the data provide in the paper, we are more than willing to be corrected. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: biopsy, elderly, Gleason score, PSA, risk, stage, Treatment | Leave a comment »
Posted on May 15, 2011 by Sitemaster
So lots of posters and and presentations this morning, but not a lot of actionable information for patients (as far a we could tell). Among the more interesting papers were the following: … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: Gleason score, MDV3100, mortality, OGX-011, positive, risk, surgical. margin | Leave a comment »
Posted on May 12, 2011 by Sitemaster
A story in Science Daily, based on new article in the Proceedings of the National Academy of Sciences (PNAS) , has suggested that blood levels of “prostasomes” may be a more accurate marker for prostate cancer risk that PSA levels in blood. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: Diagnosis, Gleason score, marker, protasome | 1 Comment »
Posted on July 6, 2010 by Sitemaster
A research group at Memorial Sloan-Kettering Cancer Center has published data indicating that translocation and/or deletion of the TMPRSS2-ERG fusion gene — which occurs in about 50 percent of the cases of clinically localized prostate cancer — is not, in fact, a prognostic indicator of risk for a more aggressive type of disease. … READ MORE …
Filed under: Diagnosis, Risk | Tagged: deletion, gene fusion, Gleason score, TMPRSSG2-ERG, translocation | Leave a comment »
Posted on June 23, 2010 by Sitemaster
A recently published Italian study has reported on whether perineural invasion (PNI) has prognostic value in patients undergoing radical prostatectomy for organ-confined prostate cancer, and on its possible correlation with other recognized prognostic factors. … READ MORE …
Filed under: Management, Treatment | Tagged: Gleason score, outcome, perineural invasion, PNI, prognosis, stage | 36 Comments »
Posted on April 16, 2010 by Sitemaster
A new article from a group in the UK suggests that there is no difference in outcomes between patients with localized disease and with Gleason scores of 4 + 3 = 7 or 3 + 4 = 7 when their PSA is ≤ 10 and they are treated with iodine-125-based, permanent seed brachytherapy. … READ MORE …
Filed under: Management, Treatment | Tagged: brachytherapy, Gleason score, localized, outcome | Leave a comment »
Posted on November 25, 2009 by Sitemaster
There have been a number of interesting reports over the past couple of days that are summarized briefly below. They encompass such topics as:
- The validity of the Epstein criteria in predicting clinically indolent prostate cancer
- MRI and MRSI in patient work-up prior to treatment for stage T1c disease
- Contrast-enhanced, color Döppler ultrasound and prostate biopsy
- Gleason scores and cancer “laterality” on biopsy and after surgery
- Accuracy of prediction of “unilateral” prostate cancer, and implications for focal surgery
- Patient age and probability of indolent disease
- Testosterone levels, comorbidities, ADT, and mortality
- A new “prostate mechanical imaging system” … READ MORE …
Filed under: Uncategorized | Tagged: ADT, age, androgen deprivation therapy, color Döppler, comorbidities, Epsetin criteria, Gleason score, magnetic resonance, mortality, MRI, MRSI, testosterone, ultrasound, unilateral | 2 Comments »
Posted on November 16, 2009 by Sitemaster
Three reports discussed today address the refinement of risk information in the diagnosis and prognosis of prostate cancer, with specific regard to:
- Whether PSA levels should be adjusted based on BMI
- The prediction of Gleason score upstaging after surgery
- Tumor volume and percent cancer as predictors of prostate cancer progression post-surgery … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: BMI, Gleason score, obesity, percent cancer, PSA, tunor volume, upstaging | Leave a comment »
Posted on November 12, 2009 by Sitemaster
Several reports have clearly shown that biochemical recurrence (a rising PSA) after first-line treatment is more common among men with a Gleason score of 4 + 3 = 7 than it is in men with a Gleason score of 3 + 4 = 7. However, there has been no confirmation of an association between these Gleason scores and risk for prostate cancer-specific death. … READ MORE …
Filed under: Living with Prostate Cancer | Tagged: Gleason score, prostate cancer-specific survival | 76 Comments »
Posted on July 8, 2009 by Sitemaster
Today’s prostate cancer news reports cover items on:
- Assessment of quality of life after radical prostatectomy
- Permanent seed brachytherapy in treatment of localized disease
- Cryotherapy in treatment of patients with Gleason 8-10 localized disease
- Actonel and/or estradiol in prevention of SREs … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: Actonel, brachytherapy, cryotherapy, estradiol, Gleason score, outcome, permanent, quality of life, risedronate, seed, survey | Leave a comment »
Posted on July 1, 2009 by Sitemaster
In today’s news reports we cover items on:
- Prediction of risk for prostate cancer under-grading based on biopsy data
- The obesity/risk equation in prostate cancer
- Capecitabine + docetaxel in metastatic CRPC … READ MORE …
Filed under: Diagnosis, Drugs in development, Management, Risk, Treatment | Tagged: biopsy, capecitabine, CRPC, docetaxel, Gleason score, obesity, risk, under-grading | Leave a comment »
Posted on April 26, 2009 by Sitemaster
The following four reports address some other interesting papers and posters presented at the AUA today. … READ MORE …
Filed under: Management, Treatment | Tagged: active surveillance, dosing, Epsetins's criteria, Gleason score, LHRH therapy, positive surgical margins | Leave a comment »
Posted on February 11, 2009 by Sitemaster
Today’s news reports contain four key items:
- A review of the potential of phytochemicals in treatment of prostate cancer
- A Norwegian study on correlation between biopsy-based and post-surgical Gleason scores
- A retrospective study on risk for prostate cancer in men being treated with testosterone replacement therapy
- An announcement of new data on PSP94 in the diagnosis of prostate cancer … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: biopsy, Gleason score, Miraculins, phytochemicals, PSP94, testosterone replacement, TRT | Leave a comment »
Posted on January 12, 2009 by Sitemaster
In addition to the comentary on outcomes of radical prostatectomy in men of 70 years and older, there are four reports in today’s news, addressing:
- Garlic as a dietary component that prevents cancer
- How “knock down” of androgen receptor expression and PCPH expression may potentially impact prostate cancer treatment
- The clinical impact of discordant post-biopsy and post-Gleason scores on outcomes in men being treated with surgery. … READ MORE …
Filed under: Drugs in development, Management, Treatment | Tagged: discordance, garlic, gene expression, Gleason score, knock down | Leave a comment »
Posted on November 29, 2008 by Sitemaster
We have separately addressed a report on 10-year outcome data following (non-robotic) laparoscopic radical prostatectomy for localized prostate cancer. In today’s other reports we have addressed:
- The potential of annexin A3 as a marker for early diagnosis of prostate cancer
- The ability of PSAV and PSAD to predict risk for prostate cancer in men with one or more negative prostate biopsies
- Estrogens, estrogen receptors, and prostate cancer development and progression
- Differences between clinical and pathological Gleason scores and the impact on outcomes following surgery … READ MORE …
Filed under: Diagnosis, Management, Treatment | Tagged: annexin, estogen, Gleason score, marker, PSA density, PSA velocity, receptor | Leave a comment »
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