Risk, prostate cancer, and being 70 to 80 years of age

So a relatively new article in Reviews in Urology caught your Sitemaster’s eye this morning — and worried him because it seemed to be communicating a conclusion of questionable accuracy, which we will explore below. And if we have misinterpreted the data provide in the paper, we are more than willing to be corrected. … READ MORE …

What’s hot at the AUA annual meeting (Sunday morning)?

So lots of posters and and presentations this morning, but not a lot of actionable information for patients (as far a we could tell). Among the more interesting papers were the following: … READ MORE …

Prostasomes — another possible marker for prostate cancer aggression?

A story in Science Daily, based on new article in the Proceedings of the National Academy of Sciences (PNAS) , has suggested that blood levels of “prostasomes” may be a more accurate marker for prostate cancer risk that PSA levels in blood. … READ MORE …

Genetic translocations and the risk for more aggressive forms of prostate cancer

A research group at Memorial Sloan-Kettering Cancer Center has published data indicating that translocation and/or deletion of the  TMPRSS2-ERG fusion gene  — which occurs in about 50 percent of the cases of clinically localized prostate cancer — is not, in fact, a prognostic indicator of risk for a more aggressive type of disease. … READ MORE …

The prognostic implications of perineural invasion at the time of surgery

A recently published Italian study has reported on whether perineural invasion (PNI) has prognostic value in patients undergoing radical prostatectomy for organ-confined prostate cancer, and on its possible correlation with other recognized prognostic factors. … READ MORE …

Brachytherapy outcomes for Gleason 7 patients by primary grade

A new article from a group in the UK suggests that there is no difference in outcomes between patients with localized disease and with Gleason scores of 4 + 3 = 7 or 3 + 4 = 7 when their PSA is ≤ 10 and they are treated with iodine-125-based, permanent seed brachytherapy. … READ MORE …

Prostate cancer news reports: Wednesday, November 25, 2009

There have been a number of interesting reports over the past couple of days that are summarized briefly below. They encompass such topics as:

  • The validity of the Epstein criteria in predicting clinically indolent prostate cancer
  • MRI and MRSI in patient work-up prior to treatment for stage T1c disease
  • Contrast-enhanced, color Döppler ultrasound and prostate biopsy
  • Gleason scores and cancer “laterality” on biopsy and after surgery
  • Accuracy of prediction of “unilateral” prostate cancer, and implications for focal surgery
  • Patient age and probability of indolent disease
  • Testosterone levels, comorbidities, ADT, and mortality
  • A new “prostate mechanical imaging system” … READ MORE …

Prostate cancer news report: Monday, November 16, 2009

Three reports discussed today address the refinement of risk information in the diagnosis and prognosis of prostate cancer, with specific regard to:

  • Whether PSA levels should be adjusted based on BMI
  • The prediction of Gleason score upstaging after surgery
  • Tumor volume and percent cancer as predictors of prostate cancer progression post-surgery … READ MORE …

Prostate cancer-specific mortality and Gleason grade

Several reports have clearly shown that biochemical recurrence (a rising PSA) after first-line treatment is more common among men with a Gleason score of 4 + 3 = 7 than it is in men with a Gleason score of 3 + 4 = 7. However, there has been no confirmation of an association between these Gleason scores and risk for prostate cancer-specific death. … READ MORE …

Prostate cancer news reports: Wednesday, July 8, 2009

Today’s prostate cancer news reports cover items on:

  • Assessment of quality of life after radical prostatectomy
  • Permanent seed brachytherapy in treatment of localized disease
  • Cryotherapy in treatment of patients with Gleason 8-10 localized disease
  • Actonel and/or estradiol in prevention of SREs … READ MORE …

Prostate cancer news reports: Wednesday, July 1, 2009

In today’s news reports we cover items on:

  • Prediction of risk for prostate cancer under-grading based on biopsy data
  • The obesity/risk equation in prostate cancer
  • Capecitabine + docetaxel in metastatic CRPC … READ MORE …

AUA report and update no. 3: Sunday, April 26, 2009

The following four reports address some other interesting papers and posters presented at the AUA today. … READ MORE …

Wednesday’s prostate cancer news: February 11, 2009

Today’s news reports contain four key items:

  • A review of the potential of phytochemicals in treatment of prostate cancer
  • A Norwegian study on correlation between biopsy-based and post-surgical Gleason scores
  • A retrospective study on risk for prostate cancer in men being treated with testosterone replacement therapy
  • An announcement of new data on PSP94 in the diagnosis of prostate cancer … READ MORE …

The Tuesday news reports: January 13, 2008

In addition to the comentary on outcomes of radical prostatectomy in men of 70 years and older, there are four reports in today’s news, addressing:

  • Garlic as a dietary component that prevents cancer
  • How “knock down” of androgen receptor expression and PCPH expression may potentially impact prostate cancer treatment
  • The clinical impact of discordant post-biopsy and post-Gleason scores on outcomes in men being treated with surgery. … READ MORE …

The Saturday prostate cancer news: November 29, 2008

We have separately addressed a report on 10-year outcome data following (non-robotic) laparoscopic radical prostatectomy for localized prostate cancer. In today’s other reports we have addressed:

  • The potential of annexin A3 as a marker for early diagnosis of prostate cancer
  • The ability of PSAV and PSAD to predict risk for prostate cancer in men with one or more negative prostate biopsies
  • Estrogens, estrogen receptors, and prostate cancer development and progression
  • Differences between clinical and pathological Gleason scores and the impact on outcomes following surgery … READ MORE …