Patients who are initially diagnosed with primary Gleason pattern 5 localized prostate cancer (i.e., having Gleason scores of 5 + 5 = 10 and 5 + 4 = 9) are well understood to have very high-risk disease. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: 5, Gleason, medicine, pattern, precision, risk | 3 Comments »
Whether whole pelvic radiation therapy (WPRT) is beneficial for men newly diagnosed with Gleason grade 9/10 (Grade Group 5) is controversial. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: 10, 9, Gleason, pelvic, primary, radiation, score, whole | 1 Comment »
A commentary in Renal and Urology News this morning is entitled “Gleason 6 prostate cancer is more lethal in black men”. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Risk | Tagged: black, Gleason, mortality, non-black, risk, score | Leave a comment »
We recently saw (see this link) that men diagnosed with a Gleason score (GS) of 9 or 10 had lower rates of metastasis and better prostate-cancer survival if … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: 10, aggressive, Gleason, Treatment | 11 Comments »
According to a study just published in Cancer Research, a completely new technique referred to as “single cell genomics” may be able to improve the accuracy of diagnosis of prostate cancer based on biopsy tissue. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: cell, dagnosis, genomics, Gleason, grade, prognosis, score, single | 2 Comments »
In a research study synthesis published in European Urology, Anthony D’Amico raises the hypothesis that androgen deprivation therapy (ADT) is most effective with Gleason pattern 4, but has lesser or no effect when prostate tumors include Gleason pattern 5. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: 5, Gleason, hypothesis, pattern | 7 Comments »
A question on the minds of many prostate cancer researchers and clinicians (not to mention their patients) is if and when we may be able to replace repeat systematic prostate biopsies for patients on active surveillance (or seeking to start on active surveillance) with the significantly less invasive multiparametric MRIs (mpMRIs). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: biopsy, Gleason, grade, MRI, multiparametric, repeat, risk, scan, score | 5 Comments »
It has been hypothesized for some time that men diagnosed with a low PSA level (i.e., < 4.0 ng/ml) but a high Gleason score (of 8, 9, or 10) are at elevated risk for more advanced disease and a shorter survival time than some others. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: Gleason, high, low, PSA, risk, score, survival | 4 Comments »
There have long been suggestions that men with high-risk disease who initially present with relatively low PSA levels (< 2.5 ng/ml) may be at higher than average risk for prostate cancer-specific mortality than men with higher PSA levels at diagnosis. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: Diagnosis, Gleason, mortality, PSA, risk, score, Treatment | Leave a comment »
There is a perception among a lot of patients — especially when they get diagnosed — that having a high Gleason score of 8, 9, or 10 is essentially a “death sentence”, regardless of how they get treated. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: biochemical, expectations, Gleason, high-grade, projections, recurrence, survival | 10 Comments »
… know the Gleason score of the tissue at that positive surgical margin as well as and as opposed to just the Gleason score of the primary tumor. It makes a difference to your risk for biochemical recurrence. Your doctors need to know this information too! … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: Gleason, margin, positive, recurrence, risk, score, size, surgical | 12 Comments »
In a recent article in the American Journal of Surgical Pathology, Khani and Epstein have argued that patients initially diagnosed with intraductal carcinoma of the prostate (IDC-P) should have this reported as a separate class of prostate cancer, with no reference to the patients’ Gleason scores. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: Gleason, grade, IDC-P, intraductal, Management, outcome, pattern, risk | 4 Comments »
A new study that is in press on line in the Journal of Urology addresses, very reasonably, the question of whether using targeted biopsy methods based on multiparametric MRI (mpMRI) data is improving our ability to accurately assess patient’s Gleason grades and scores prior to decisions about treatment. … READ MORE …
Filed under: Diagnosis, Management, Risk | Tagged: accuracy, biopsy, Gleason, MRI, multiparamentric, targeted | 7 Comments »
The “New” Prostate Cancer InfoLink has taken the position for quite a while that active surveillance could well be a highly appropriate management strategy for some men with a Gleason score of 3 + 4 = 7 at diagnosis (but far from all of them) — if they still met certain other criteria as good candidates for this form of management. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk | Tagged: 3 + 4 = 7, active, Gleason, hypothesis, surveillance | 3 Comments »
THE "NEW" PROSTATE CANCER INFOLINK 