Not all men with Gleason 8-10 disease are going to do badly after treatment

There is a perception among a lot of patients — especially when they get diagnosed — that having a high Gleason score of 8, 9, or 10 is essentially a “death sentence”, regardless of how they get treated. … READ MORE …

If you have positive surgical margins post-surgery, you need to …

… know the Gleason score of the tissue at that positive surgical margin as well as and as opposed to just the Gleason score of the primary tumor. It makes a difference to your risk for biochemical recurrence. Your doctors need to know this information too! … READ MORE …

Intraductal carcinoma of the prostate: of risk, outcomes, and Gleason scores

In a recent article in the American Journal of Surgical Pathology, Khani and Epstein have argued that patients initially diagnosed with intraductal carcinoma of the prostate (IDC-P) should have this reported as a separate class of prostate cancer, with no reference to the patients’ Gleason scores. … READ MORE …

mpMRIs, targeted biopsies, and the accuracy of Gleason grading

A new study that is in press on line in the Journal of Urology addresses, very reasonably, the question of whether using targeted biopsy methods based on multiparametric MRI (mpMRI) data is improving our ability to accurately assess patient’s Gleason grades and scores prior to decisions about treatment. … READ MORE …

Active surveillance for men with Gleason 3 + 4 = 7 disease

The “New” Prostate Cancer InfoLink has taken the position for quite a while that active surveillance could well be a highly appropriate management strategy for some men  with a Gleason score of 3 + 4 = 7 at diagnosis (but far from all of them) — if they still met certain other criteria as good candidates for this form of management. … READ MORE …

SNP on chromosome 19 may be good biomarker for aggressive Gleason 7 disease

An article just published on line in Clinical Cancer Research supposedly reports the discovery of a single nucleotide polymorphism or SNP that may be useful in predicting which patients with Gleason 7 disease are most likely to have a more aggressive form of cancer. … READ MORE …

Mortality, body mass index, and Gleason score: the relationship

New data appear to suggest that you really don’t want to be diagnosed with high-risk prostate cancer if you are significantly over-weight or obese. … READ MORE …