Could “single cell genomics” replace Gleason grading in prostate cancer risk evaluation?

According to a study just published in Cancer Research, a completely new technique referred to as “single cell genomics” may be able to improve the accuracy of diagnosis of prostate cancer based on biopsy tissue. … READ MORE …

Height IS a risk factor for higher-risk prostate cancer

A newly published and very detailed paper based on data from the PRACTICAL consortium now seems to have confirmed that taller men are at greater risk for high-risk prostate cancer than shorter ones (like your sitemaster). … READ MORE …

A high-grade ego with high-grade prostate cancer

For those who have either forgotten or never knew who Craig Venter is or was, here’s an update: he recently had surgical treatment for “high-grade” prostate cancer. … READ MORE …

New grade group system predicts risk for prostate cancer-specific mortality

According to a report on the Renal & Urology News web site this morning, a new paper about to be published on line in European Urology (by He et al.) has shown that the new ISUP staging system can be used to project risk for prostate cancer-specific mortality, “regardless of treatment received or clinical stage at diagnosis”. … READ MORE …

A new urine test to assess risk for prostate cancer?

Apparently a newly developed type of urine test — an RNA-based “urine exosome gene expression assay” — has the potential to differentiate between risk for high-grade prostate cancer (Gleason score ≥ 7) and low-grade prostate cancer (Gleason score 6) or benign disease. … READ MORE …

mpMRIs vs. biopsies for repeat evaluations on active surveillance

A question on the minds of many prostate cancer researchers and clinicians (not to mention their patients) is if and when we may be able to replace repeat systematic prostate biopsies for patients on active surveillance (or seeking to start on active surveillance) with the significantly less invasive multiparametric MRIs (mpMRIs). … READ MORE …

Intraductal carcinoma of the prostate: of risk, outcomes, and Gleason scores

In a recent article in the American Journal of Surgical Pathology, Khani and Epstein have argued that patients initially diagnosed with intraductal carcinoma of the prostate (IDC-P) should have this reported as a separate class of prostate cancer, with no reference to the patients’ Gleason scores. … READ MORE …

Increasing our ability to predict who really needs to be biopsied

Data from a large study reported in the July issue of the Journal of the National Cancer Institute has confirmed the potential ability of a four-kallikrein marker test to lower the need for biopsies in men at risk for prostate cancer while delaying diagnosis of high-grade cancers in a few men. … READ MORE …

SNP on chromosome 19 may be good biomarker for aggressive Gleason 7 disease

An article just published on line in Clinical Cancer Research supposedly reports the discovery of a single nucleotide polymorphism or SNP that may be useful in predicting which patients with Gleason 7 disease are most likely to have a more aggressive form of cancer. … READ MORE …

What is PI-RADS and why should you care?

PI-RADS is an acronym and it stands for “prostate imaging — reporting and data system” but what it really is is a highly structured method for reporting what can be seen on certain types of prostate-specific magnetic resonance imaging (MRI) scan and how to interpret these data. … READ MORE …

How low is the risk for Gleason score progression over time?

A new study report in Cancer Research suggests that: (a) prostate cancer aggressiveness may be established when the initial tumor is formed and not alter over time; (b) active surveillance or similar monitoring strategies really are the most appropriate initial management option for men with low-grade, low-risk cancer (potentially regardless of their age at diagnosis). … READ MORE …

Test your knowledge on the diagnosis and staging of prostate cancer

Support group leaders and other prostate cancer educators may wish to test their knowledge on the diagnosis and staging of prostate cancer by reading through the set of 29 slides prepared by Kleynberg and Gross and just made available on the Medscape web site.

A real decrease in the use of RP in treatment of men with low-risk prostate cancer?

A new paper from clinical research teams at two French hospitals suggests that there has been a significant relative increase (from 2005 to 2010, at their institutions) in the percentage of men found to have pathological T3 as opposed to pathological T2 disease after radical prostatectomy (RP). … READ MORE …

OMG … The finger length/prostate cancer risk hypothesis is back again

In July 2010 we commented on an article in The Daily Mail that was based on data from a team of Korean researchers who’d been busily measuring the lengths of the second and fourth fingers of the right hands of men presenting at their urology clinic. They were convinced that there was a correlation between relative finger length and risk for prostate cancer. … READ MORE …

Prostate cancer web sites for the “reading challenged”

A new paper in the Journal of Urology has criticized most prostate cancer web sites written for patients because they are not written at an 8th or 9th grade reading skill level (a skill level considered to be available to most American males). … READ MORE …