PSA velocity no better than latest PSA value in screening men carrying BRCA1/2 genes

Data from the ongoing, prospective IMPACT study has shown that PSA velocity is not predictive of risk for a positive prostate cancer biopsy result in men who are carriers of the BRCA2 gene. … READ MORE …

State of the art lectures at the EAU meeting in London

Recently posted on the UroToday web site are summaries of four “state-of-the-art” lectures on prostate cancer and its management presented a couple of weeks ago at the annual meeting of the European Association of Urology is London. … READ MORE …

Prostate cancer-specific mortality and diagnosis with BRCA1/2-positive disease

A new study just published on line in the Journal of Clinical Oncology had confirmed that “BRCA1/2 mutations confer a more aggressive [prostate cancer] phenotype with a higher probability of nodal involvement and distant metastasis.” This is not a surprising finding, but it does have real implications for men with a family history of BRCA1/2 mutations. … READ MORE …

Rare G84E mutation strongly associated with familial (inherited) prostate cancer

A new study has confirmed an initial finding that the rare G84E mutation (also known as rs138213197) in the HOXB13 gene is a significant driver of risk for prostate cancer among men with a family history of the disease. … READ MORE …

An update on hereditary and familial prostate cancers

For those interested in “brushing up” on their understanding of the risks associated with hereditary and familial forms of prostate cancer, we recommend a brief article in the April issue of the AUA News, which summarizes a “state of the art” lecture to be given by the author at the upcoming annual meeting of the American Urological Association. … READ MORE …

More weekend prostate cancer news: Sunday, August 17

Additional prostate cancer news this weekend includes the following items:

  • The role of follow-up pathology in patients with clinical stage T1a (TURP-detected) prostate cancer
  • The impact of the number of risk factors on the likelihood of prostate cancer-specific mortality in patients with intermediate- and high-risk disease
  • Whether a familial history of prostate cancer affects outcomes following brachytherapy for localized disease
  • Whether obese men are at greater risk for delayed diagnosis of prostate cancer and subsequent poorer outcomes based on current PSA screening recommendations … READ MORE …