What we need to tell sons and grandsons about their risk for prostate cancer

Over the past few years, with the increased focus on the idea of “personalized” medicine, we have become increasingly informed about and focused on correlations between genetics and genomics and risk for prostate cancer. However, … READ MORE …

PSA velocity no better than latest PSA value in screening men carrying BRCA1/2 genes

Data from the ongoing, prospective IMPACT study has shown that PSA velocity is not predictive of risk for a positive prostate cancer biopsy result in men who are carriers of the BRCA2 gene. … READ MORE …

State of the art lectures at the EAU meeting in London

Recently posted on the UroToday web site are summaries of four “state-of-the-art” lectures on prostate cancer and its management presented a couple of weeks ago at the annual meeting of the European Association of Urology is London. … READ MORE …

Prostate cancer-specific mortality and diagnosis with BRCA1/2-positive disease

A new study just published on line in the Journal of Clinical Oncology had confirmed that “BRCA1/2 mutations confer a more aggressive [prostate cancer] phenotype with a higher probability of nodal involvement and distant metastasis.” This is not a surprising finding, but it does have real implications for men with a family history of BRCA1/2 mutations. … READ MORE …

Rare G84E mutation strongly associated with familial (inherited) prostate cancer

A new study has confirmed an initial finding that the rare G84E mutation (also known as rs138213197) in the HOXB13 gene is a significant driver of risk for prostate cancer among men with a family history of the disease. … READ MORE …

An update on hereditary and familial prostate cancers

For those interested in “brushing up” on their understanding of the risks associated with hereditary and familial forms of prostate cancer, we recommend a brief article in the April issue of the AUA News, which summarizes a “state of the art” lecture to be given by the author at the upcoming annual meeting of the American Urological Association. … READ MORE …

More weekend prostate cancer news: Sunday, August 17

Additional prostate cancer news this weekend includes the following items:

  • The role of follow-up pathology in patients with clinical stage T1a (TURP-detected) prostate cancer
  • The impact of the number of risk factors on the likelihood of prostate cancer-specific mortality in patients with intermediate- and high-risk disease
  • Whether a familial history of prostate cancer affects outcomes following brachytherapy for localized disease
  • Whether obese men are at greater risk for delayed diagnosis of prostate cancer and subsequent poorer outcomes based on current PSA screening recommendations … READ MORE …