HIFU as first-line therapy in intermediate- and high-risk patients

A report from an Italian clinical research group has offered data from > 150 patients treated with high-intensity focused ultrasound (HIFU) with an average of > 5 years of follow-up. … READ MORE …

Outcomes after HIFU and prognosis based on post-HIFU PSA nadir levels

A new analysis of data from the multi-center @-Registry of patients undergoing Ablatherm-based high-intensity focused ultrasound (HIFU) for the treatment of localized prostate cancer suggests that nadir levels of PSA post-treatment can be used to predict the probability of biochemical progression-free survival (bPFS) at 5 years of follow-up. … READ MORE …

Focal (hemiablative) HIFU in the treatment of localized prostate cancer

To date there have been few data from well-documented, prospective series of patients receiving any form of focal therapy as treatment for localized prostate cancer, and the criteria for the appropriate clinical use of focal therapy are still a matter of considerable debate. … READ MORE …

5-year outcomes data from a French series of HIFU patients

A new report from a French research team has provided detailed 5-year data on the oncological outcomes of a series of low- and intermediate-risk prostate cancer patients treated with high-intensity ultrasound (HIFU) using second-generation Ablatherem™ equipment. … READ MORE …

An unenthusiastic review of HIFU in prostate cancer

The potential value of high-intensity focused ultrasound (HIFU) as a treatment for prostate cancer continues to foment controversy between its advocates and its detractors. … READ MORE …

A new review of recent clinical outcomes after HIFU

High-intensity focused ultrasound (HIFU) continues to gain advocates as a minimally invasive form of treatment for patients with localized and locally advanced prostate cancer, as well as for patients requiring salvage therapy after first-line radiation and after radical prostatectomy. … READ MORE …

Bladder outlet obstruction: a common side effect of HIFU

The occurrence of bladder outlet obstruction (BOO) as a complication following the use of high-intensity focused ultrasound (HIFU) in the treatment of prostate cancer has been widely recognized since the early, investigational use of HIFU in the 1990s. … READ MORE …

Canadian practice guideline does NOT recommend HIFU

High-intensity focused ultrasound (HIFU) is legally available in Canada as a method for the treatment of prostate cancer. However, a new Canadian practice guideline states that, “HIFU cannot currently be recommended as an alternative to accepted curative treatment approaches for localized prostate cancer.” … READ MORE …

Oncologic outcomes of HIFU for localized prostate cancer in 800+ patients

An article still to be formally published in European Urology provides data on the outcomes of 803 patients with localized prostate cancer, all treated with high-intensity focused ultrasound (HIFU) between 1993 and 2007 at six centers in France. … READ MORE …

Post-treatment pathology of the prostate after first-line HIFU

One of the unknown factors in the use of high-intensity focused ultrasound (HIFU) for the first-line treatment of prostate cancer is the potential for high-quality, biochemical recurrence-free survival over time. Post-treatment histopathology may offer some insight into the likelihood of good outcomes. … READ MORE …

HIFU as salvage therapy for radiation failure

One of the proposed uses for high-intensity focused ultrasound (HIFU)  has been as a treatment option for men with a rising PSA after first-line treatment with external beam radiation therapy (EBRT). … READ MORE …

HIFU is not necessarily as safe as suggested

We want to again make the point that treatment of localized prostate cancer with high-intensity focused ultrasound (HIFU), in the hands of inexperienced clinicians, is not necessarily as safe as some of the sales pitches might suggest. In the hands of highly experienced or highly trained HIFU practioners, with access to second- and third-generation equipment, the results may be different. … READ MORE …

What the Belgian health authorities think about HIFU

We have learned that last October the “Federaal Kenniscentrum voor de Gezondheidszorg”  or KCE in Brussels, Belgium (the “Federal Center for Health Care Knowledge”) published a guidance document on the current use of high-intensity focused ultrasound (HIFU) for the treatment of localized prostate cancer. … READ MORE …

Japanese experience with HIFU over 8 years

Investigators at Tokai University Hachioji Hospital in Tokyo have been using high-intensity, focused ultrasound (HIFU) to treat men with localized prostate cancer since January 1999. A newly-published paper provides a complete report on this experience. … READ MORE …

HIFU for localized prostate cancer: a series of 172 UK patients

The following commentary reports with greater accuracy and in more detail on the same article, dealing with the same series of 172 HIFU patients, as was previously discussed on this web site on July 2 this year. The original report was based solely on the abstract of the article. … READ MORE …