Posted on June 6, 2020 by Sitemaster
Last month, we looked at Level 1 evidence (highest level, superseding all previous studies) that for unfavorable-risk patients, brachy boost therapy (BBT) — i.e., external beam therapy (EBRT) with a brachytherapy boost to the prostate — has better results when accompanied by 18 months of androgen deprivation therapy (ADT) (see this link). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Treatment | Tagged: ADT, brachy boost, high, intermediate, radiation, risk, therapy | 3 Comments »
Posted on September 2, 2019 by Sitemaster
Data from a recently published, Canadian, clinical trial of high-dose vitamin D as a method to strengthen bones in healthy adults who do not have osteoporesis have had significant and unexpectedly negative results. … READ MORE …
Filed under: Living with Prostate Cancer, Management, Treatment | Tagged: dose, high, outcome, randomized, trial, vitamin D | 18 Comments »
Posted on July 5, 2018 by Sitemaster
A new paper from the Emberton-Ahmed group in the UK has reported 5-year follow-up data from a cohort of > 600 patients with clinically significant, localized prostate cancer, all treated with focal forms of high-intensity focused ultrasound (HIFU). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: focal, HIFU, high, high-intensity, intermediate, risk, ultrasound | 7 Comments »
Posted on October 26, 2017 by Sitemaster
The first randomized clinical trial to prove that brachy boost radiotherapy had better oncological outcomes among high-risk patients was the one published by Sathya et al. in 2005. … READ MORE …
Filed under: Diagnosis, Management, Treatment | Tagged: boost, brachy, high, intermediate, outcome, radiation, risk, survival | 6 Comments »
Posted on March 16, 2017 by Sitemaster
Several randomized clinical trials have established the superior oncological outcomes of the combination of external beam radiotherapy with a high-dose-rate brachytherapy boost (see this link). … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: boost, brachytherapy, high, intermediate, progression-free, risk, survival | 1 Comment »
Posted on January 9, 2016 by Sitemaster
The EORTC trial 22991 was designed and implemented to compare external beam radiation therapy (EBRT) + short-term androgen deprivation therapy (ADT) to EBRT alone as first-line therapy in patients with intermediate- and high-risk prostate cancer. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: ADT, androgen, deprivation, EBRT, external beam, high, intermediate, radiation, risk | 5 Comments »
Posted on November 9, 2015 by Sitemaster
It has been hypothesized for some time that men diagnosed with a low PSA level (i.e., < 4.0 ng/ml) but a high Gleason score (of 8, 9, or 10) are at elevated risk for more advanced disease and a shorter survival time than some others. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: Gleason, high, low, PSA, risk, score, survival | 4 Comments »
Posted on November 6, 2015 by Sitemaster
From the perspective of the disinterested observer, one of the very least edifying aspects of issues related to the management of prostate cancer has been the nearly 50-year-long “discussion” between the urology community and the radiation oncology community about the most appropriate way(s) to treat localized disease. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: "best", high, intermediate, localized, registry, risk, Treatment, trial | 11 Comments »
Posted on November 2, 2015 by Sitemaster
The ASCENDE-RT randomized clinical trial demonstrated that the combination of external beam radiation therapy with a brachytherapy boost (EBRT + BT) significantly reduced biochemical progression-free survival. … READ MORE …
Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment | Tagged: boost, brachytherapy, BT, EBRT, external beam, high, intermediate, mortality, outcome, radiation, risk | 3 Comments »
Posted on July 2, 2015 by Sitemaster
Sometimes, when patients originally present with very high PSA levels, a negative bone scan, and a negative CT scan, they are put on permanent androgen deprivation therapy (ADT) because the doctor just assumes it is micrometastatic. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: efficacy, high, outcome, PSA, Treatment | 2 Comments »
Posted on February 16, 2012 by Sitemaster
A new report from a Scottish research team offers evidence that high plasma cholesterol levels are associated with an increased risk for a diagnosis of high-grade prostate cancer. … READ MORE …
Filed under: Diagnosis, Prevention, Risk | Tagged: cholesterol, grade, high, risk | 4 Comments »
Posted on August 11, 2011 by Sitemaster
A new French study has attempted to provide a better appreciation of the effect of predictive factors on the biochemical recurrence-free and overall survival of patients with high-risk prostate cancer after a radical prostatectomy (RP). … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: high, outcome, prediction, radical prostatectomy, risk | 4 Comments »
Posted on April 11, 2011 by Sitemaster
There is an interesting report today from an Italian clinical research team on the outcomes of radical prostatectomy in men with higher than normal PSA levels (i.e., 20 ng/ml and higher) at time of diagnosis. We know that all prostate cancer patients with PSA levels > 20 ng/ml are now customarily classified as having high-risk disease. … READ MORE …
Filed under: Diagnosis, Management, Risk, Treatment | Tagged: high, outcome, PSA, radical prostatectomy, very | 1 Comment »
Posted on December 9, 2010 by Sitemaster
Overall life expectancy of men in the US continues to rise. As a consequence, the way we treated localized prostate cancer in men of ≥ 70 years of age in 1990 will probably not be relevant or appropriate to the way we need to treat such men in 2020 (or perhaps even today). … READ MORE …
Filed under: Uncategorized | Tagged: age, elderly, high, localized, risk, Treatment | 2 Comments »
THE "NEW" PROSTATE CANCER INFOLINK 