Should we be calling “hormone therapy” for prostate cancer a spade?

When women and their doctors talk about “hormone therapy” they are most commonly referring to the (now) highly controversial issue of whether hormonal supplements (estrogen and progesterone) should be used at and after menopause to prevent the symptoms of menopause and/or later risks related to heart disease and osteoporesis. … READ MORE …

IAD vs. CAD in men with hormone-sensitive, metastatic prostate cancer

Today at the ASCO annual meeting, Maha Hussein presented the results a long-term, international, randomized trial of intermittent androgen deprivation (IAD) versus continuous androgen deprivation (CAD) in men with hormone-sensitive, metastatic prostate cancer. … READ MORE …

Patient satisfaction after first-line treatment for localized prostate cancer (in Germany)

A new article in the journal Anticancer Research suggests that patients had greater satisfaction after modern forms of external beam radiation therapy (EBRT) than after some other standard forms of first-line treatment. Of course the absolute truth of this conclusion may be affected by the details of the study. … READ MORE …

Limited value of immediate, adjuvant ADT in men with pT3b prostate cancer

New data published by clinical researchers at the Mayo Clinic have suggested that there is no overall survival benefit associated with adjuvant hormone therapy after surgery in men with pathological T3b disease. … READ MORE …

Neoadjuvant hormone therapy for patients undergoing first-line radiation therapy

The Irish Clinical Oncology Research Group trial 97-01 was a randomized clinical trial designed to compare the long-term outcomes of patients treated with either 4 months or 8 months of hormonal therapy given before external beam radiotherapy for localized prostate cancer. … READ MORE …

The long-term survival of patients with metastatic prostate cancer

In the late 1980s and early 1990s it was generally considered that men diagnosed with metastatic (but still hormone sensitive) prostate cancer had an estimated survival of 18 to 36 months from the time of diagnosis — including their time on treatment with hormonal therapy. … READ MORE …

Sunday at the ASCO annual meeting

There were a number of significant prostate cancer presentations today, and while none of them were “game changing” (for a variety of reasons), they are certainly worthy of notice. … READ MORE …

Relapse-free survival of non-metastatic patients treated with primary androgen deprivation

Many patients with no specific evidence of metastatic disease now receive primary androgen deprivation therapy (PADT) much earlier than was the case before the availability of the PSA test. This includes patients who get hormone therapy for a rising PSA after other forms of first-line therapy and patients who receive hormone therapy as their first-line treatment. … READ MORE …

Hormone therapy effective in man with PSA > 21,000, but …

An article in just published in Onkologie reports the diagnosis and (short-term) treatment of widely disseminated, metastatic prostate cancer in a 64-year-old Croatian man with a PSA of > 21,000 ng/ml. … READ MORE …

Short-term ADT with RT for localized prostate cancer

The RTOG 94-08 clinical trial was designed to test the idea that just 4 months of hormone therapy, administered  before and during radiation therapy, would improved the overall survival of patients diagnosed with clinical stage T1b-T2b prostate cancer and a PSA level equal to or lower than 20 ng/ml. … READ MORE …

Prostate cancer news report: Sunday, January 24, 2010

In this weekend’s prostate cancer news reports, we have addressed recent publications on:

  • A SNP that may be specifically linked to risk for prostate cancer in African Americans
  • The need for extended biopsies in men with larger prostates who are considering focal treatment for prostate cancer
  • A possible association between diabetes, race, obesity, and risk for prostate cancer progression
  • Neoadjuvant hormone therapy, brachytherapy, and all cause mortality in older patients … READ MORE …

Prostate cancer news reports: Wednesday, January 13, 2010

Today’s news reports summarize papers recently published on:

  • Optimism, pessimism, and long-term health outcomes
  • External beam radiation + hormone therapy for high-risk patients
  • Quality of life and health utility after radical prostatectomy
  • Paclitaxel + estradiol combination therapy in men progressing after docetaxel-based chemotherapy … READ MORE …

Hormone therapy not helpful for low-risk patients receiving first-line radiation

A report presented yesterday in Chicago, at the annual meeting of the American Society for Radiation Oncology (ASTRO), suggests that short-term hormone therapy given prior to and during first-line radiation treatment to intermediate-risk prostate cancer patients increases their chance of living longer, compared to those who receive radiation alone. However, the same study also showed that there is no significant benefit for low-risk patients. … READ MORE …

Prostate cancer news reports: Wednesday, September 23, 2009

Today’s news reports cover items on:

  • Extent and number of biopsy cores and eligibility for active surveillance
  • Intermittent vs. complete androgen deprivation
  • Hormone therapy and risk for cardiovascular disease and death
  • Surrogate markets for disease progression in men with CRPC … READ MORE …

Adding hormone therapy to brachytherapy: what works best?

A recent report in the International Journal of Radiation Oncology • Biology • Physics suggests that the type of hormone therapy used in combination with brachytherapy for treatment of localized prostate cancer makes no difference to the patients’ long-term outcomes. … READ MORE …