Outcomes, survival, and HRQOL in trials of new drugs (and what they mean in practice)

A new paper in the journal Quality of Life Research has raised the question of whether it is possible to use available quality of life data from Phase III trials of new drugs in the treatment of advanced prostate cancer to make rational decisions about the use of those drugs in clinical practice. … READ MORE …

Patients’ sexual orientation and communication with healthcare providers

The ability and willingness of physicians to discuss issues related to sex, sexual function, and specific sexual activities with their patients (and their partners) before or after prostate cancer treatment is notoriously not seen to be high by most prostate cancer patients (although there are exceptions to that general rule). … READ MORE …

Prostate cancer treatment outcomes among gay men

A poster presentation given on Sunday at the AUA annual meeting (and an associated media briefing) strongly suggested that gay males diagnosed with prostate cancer tend to have less good clinical outcomes than straight males. … READ MORE …

Surgery, brachytherapy, HRQOL, and the SPIRIT trial

The Surgical Prostatectomy versus Interstitial Radiation Intervention Trial or SPIRIT was a Phase III, partially randomized clinical trial, conducted in the U.S.A. and Canada, and designed to compare radical prostatectomy (RP) and brachytherapy (BT) as first-line treatments for men with localized prostate cancer. … READ MORE …

Diabetes and quality of life among men with prostate cancer

It has long been recognized that the combination of prostate cancer and diabetes tends to have a notable impact on the health-related quality of life (HRQoL) of male patients. … READ MORE …

Quality of life after first-line treatment: a prospective, comparative study

Data to be published in the May 2010 issue of the Journal of Urology are going to make a lot of urologists rather less than happy about the implications for the use of radical prostatectomy as first-line treatment for prostate cancer. … READ MORE …

Prostate cancer news reports: Wednesday, January 13, 2010

Today’s news reports summarize papers recently published on:

  • Optimism, pessimism, and long-term health outcomes
  • External beam radiation + hormone therapy for high-risk patients
  • Quality of life and health utility after radical prostatectomy
  • Paclitaxel + estradiol combination therapy in men progressing after docetaxel-based chemotherapy … READ MORE …

Partnership status and quality of life

Having high socioeconomic status AND being in a strong, positive, and supportive relationship may have improved the health-related quality of life (HRQOL) of men with localized prostate cancer, according to a recent study. … READ MORE …

First-line therapy for localized prostate cancer: outcomes and HRQOL

The decisions patients and their doctors make about which treatment to select as first-line therapy for localized prostate cancer are commonly based on perceptions and expectations about the side effects of these treatments, as well as on the curative potential of the therapy. … READ MORE …

The news report: Friday, April 17, 2009

In today’s news reports we address:

  • Prediction of freedom from biochemical failure after brachytherapy
  • Prediction of probability of unilateral prostate cancer in men eligible for focal therapy
  • Health-related quality of life 5 years after radiotherapy + androgen deprivation
  • Androgen receptor activity “signatures” in men with CRPC … READ MORE …

Anxiety predicts early use of hormone therapy

It is well known to readers of The “New” Prostate Cancer InfoLink that androgen deprivation therapy (ADT) is a commonly used form of treatment for patients who experience biochemical recurrence (BCR) after first- or second-line therapy. However, as is also well known, the optimal timing of ADT initiation is uncertain, and earlier initiation of ADT can cause toxicities that lower patients’ health-related quality of life (HRQOL). … READ MORE …

Friday’s news reports: February 20, 2009

There are several news items again today. They deal with:

  • Health-related quality of life of disadvantaged prostate cancer patients
  • Post-surgical continence and preservation of the lateral fascia
  • Relative health-related quality of life after radical prostatectomy and brachytherapy
  • The activities of the protease-activated receptors PAR1 and PAR2
  • Lymph node assessment and lymphadenectomy in management of prostate cancer
  • Associations between total and ionized serum calcium and prostate cancer mortality … READ MORE …

The Friday news reports: January 2, 2009

Today’s news report contains items on:

  • The estimation of localized prostate cancer tumor size based on PSA data alone
  • Mitochondrial genes and prostate cancer risk
  • Results of a Phase II trial of strontium-89 with chemohormonal therapy in men with metastatic bone disease
  • The association between spirituality and quality of life in low-income patients with metastatic disease

We have provided separate reports on the results of a clinical trial of flaxseed in men diagnosed with prostate cancer pre-treatment and on the 5-year outcomes of younger men treated with brachytherapy as first-line therapy for localized prostate cancer. … READ MORE …