The ASCO Genitourinary Cancers Symposium: a brief report

Your sitemaster is gradually “coming back to life” after a rather unpleasant week that included his trip to the GU Cancers Symposium (when he should probably have been in his bed at home). So here is the quick summary from Orlando. … READ MORE …

Immunotherapy for the treatment of prostate cancer

The Society for Immunotherapy of Cancer has just issued a detailed statement on the role of immunotherapy in the management of prostate cancer. The full text of this article by McNeel et al. is available on line. … READ MORE …

ADT + sipuleucel-T in treatment of hormone-sensitive prostate cancer

One of the major unanswered questions at this time is whether immunotherapy of some type, if given early to patients with prostate cancer, can help to lower risk of progression of the disease. … READ MORE …

New immunotherapeutics aren’t working well when combined with standard forms of care

A newly published article in the journal Science Translational Medicine has questioned the merits of treating prostate cancer patients with immunotherapies while they are simultaneously being treated with medical forms of castration (androgen deprivation therapy or ADT), chemotherapy, and/or radiation therapy. … READ MORE …

What’s a clonal neoantigen when it’s at home? And why is it important?

Many readers of this blog will be aware of the development of immunotherapies like sipuleucel-T (Provenge), CAR-T for the treatment of leukemias, and checkpoint inhibitors in the treatment of some forms of solid tumor (lung cancers, melanoma). … READ MORE …

New trial of investigational immunotherapy in men on active surveillance

There appears to be a high degree of confidence that Barvarian Nordic’s Prostvac will show positive results in the ongoing Phase III clinical trial in men with metastatic, castration-resistant prostate cancer. An early stage trial has now been initiated among men with much less advanced disease disease. … READ MORE …

Current thinking about immunotherapy in prostate cancer

A number of readers will probably be interested in reading at least part of an interview with Dr. Susan Slovin of the Memorial Sloan Kettering Cancer Center that has just been published on the CancerNetwork web site. … READ MORE …