Image guidance technology and radiation therapy for localized prostate cancer

Prostate cancer patients who are to be treated with any type of intensity-modulated radiation therapy (IMRT) for localized prostate cancer today can be pardoned if they are confused by the many ways in which that radiation therapy can be aimed and targeted through the use of image guidance (IGRT) systems. The variety of methods is significant and growing. … READ MORE …

Relative cost-effectiveness of SBRT and IMRT in treatment of localized prostate cancer

A new paper in the Journal of Oncology Practice has attempted to compare the cost-effectiveness of stereotactic body radiation therapy (SBRT) to that of intensity-modulated radiation therapy (IMRT) in the treatment of men with low- to intermediate-risk prostate cancer. … READ MORE …

PBRT vs. IMRT — are we about to get the definitive trial?

According to an article in the Boston Globe this morning, we are (supposedly and finally) going to get the study needed to try to demonstrate whether there is a real clinical benefit to proton beam radiation therapy as compared to modern, intensity-modulated radiation therapy in men with localized prostate cancer! … READ MORE …

Can the PACE study resolve key questions about treatment of localized prostate cancer?

According to a media release from Accuray, Inc., the company has initiated a multi-center, multinational clinical trial in Europe to compare the outcomes of patients with localized prostate cancer treated with CyberKnife stereotactic body radiation therapy (SBRT), da Vinci robot-assisted laparoscopic surgery (RALP),  manual laparoscopic surgery (LRP), and conventionally fractionated intensity modulated radiation therapy (IMRT). … READ MORE …

Relative value of 3D-CRT, IMRT, and PBRT in prostate cancer published in JAMA

In February we reported on a presentation by Sheets et al. at the Genitourinary Cancer Symposium. The presentation addressed the comparative effectiveness and safety of  3D conformal, intensity-modulated, and proton beam forms of radiation therapy (3D-CRT, IMRT, and PBRT, respectively). … READ MORE …

First directly comparative data question safety of PBRT vs. IMRT

For the first time, some 15 years after proton beam radiation therapy (PBRT) was initially popularized as a potential treatment for prostate cancer by the group at Loma Linda, we have an independent assessment of the risk for side effects associated with this form of radiation therapy … and the comparative data are not good. … READ MORE …

Self-referral and the role of IMRT in treatment of prostate cancer

The issue of whether some urology practices are investing in equipment capable of delivering intensity-modulated radiation therapy (IMRT) with financial motives is back on the front burner again. … READ MORE …

Magnesium oxide and prostate movement during radiation therapy

It has previously been proposed by some researchers that daily dosing with magnesium oxide (MgO) — alone or as part of an antiflatulent dietary regimen — can be used to reduce prostate motion (in combination with fiducial markers) during external beam radiation therapy for localized prostate cancer. … READ MORE …

Acute and mid-term side effects of high-dose, image-guided IMRT in first-line treatment of localized prostate cancer

Two recent papers have reported data relevant to the application of high-dose, image-guided, intensity-modulated forms of radiation therapy (IGRT/IMRT) in the first-line treatment of men with localized prostate cancer. … READ MORE …

How much hypofractionated IMRT is too much for localized prostate cancer?

A report to be presented at the upcoming meeting of the American Society for Radiation Oncology (ASTRO) offers 5-year outcome data from a trial comparing conventional intensity-modulated radiation therapy (IMRT) to the more recently developed hypofractionated IMRT for men with localized prostate cancer. … READ MORE …

All the different types of external beam radiation therapy for prostate cancer: a good introduction

Over the past 20 years there has been an explosion in the different ways that we use varied types of external beam radiation therapy for the treatment of localized and locally advanced forms of prostate cancer. Where is the newly diagnosed patient able to find a good, basic introduction? … READ MORE …

Toxic side effects of adjuvant, salvage IMRT post-surgery

Prostate cancer patients are commonly concerned about the potential risks for side effects associated with adjuvant and salvage radiation therapy after a preceding, first-line, radical prostatectomy. … READ MORE …

GI toxicity, radiation therapy, and androgen deprivation

For men undergoing the combination of external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT), for treatment of prostate cancer there is a significant risk for gastrointestinal (GI) toxicity over time. … READ MORE …

10-year outcomes after high-dose IMRT for localized prostate cancer

A new report from Memorial Sloan-Kettering Cancer Center has documented patient outcomes at 10 years after high-dose, intensity-modulated radiation therapy (IMRT)  for men initially diagnosed with clinically localized prostate cancer. … READ MORE …

Other prostate cancer news: Wednesday, December 8, 2010

Other prostate cancer news out today includes:

  • An article in the Wall Street Journal about the financial motives behind intensity-modulated radiation therapy (IMRT)
  • Approval from the FDA for a Phase III pivotal trial of PROSTVAC-VF … READ MORE …