Can Cytori Cell Therapy change the way we treat long-term male incontinence post-surgery?

What is described as an open-label, multi-center, single-arm study (the ADRESU trial) has opened in Japan to evaluate the efficacy and safety of periurethral injection of autologous adipose-derived regenerative cells (ADRCs) for the treatment of male stress urinary incontinence resulting from radical prostatectomy (or from transurethral resction of the prostate). … READ MORE …

The side effects of radical prostatectomy: a new review

A new review article by a Danish research team in the Journal of Sexual Medicine has (arguably) brought a degree of clarity to what the authors refer to as “neglected” side effects consequent to radical prostatectomy. Unfortunately the average urologist probably doesn’t read the Journal of Sexual Medicine on a regular basis. … READ MORE …

Stem cells from fat and the management of post-surgical incontinence

Credit where credit is due. … Our friends at The Daily Mail in England have actually come up with some prostate cancer-related news worth passing on! … READ MORE …

Managing common side effects of radical prostatectomy

We have already mentioned the article on genomics and biomarkers in this month’s issue of AUA News, but there are two other articles in this issue of the publication that are likely to be of interest to at least some of our regular readers. … READ MORE …

1 in 20 RP patients need further surgery for incontinence within 15 years

A study just published in the Journal of Urology has suggested that (at least among patients in Ontario, Canada) one in every 20 men who undergo radical prostatectomy (RP) for treatment of localized prostate cancer will — within the following 15 years — require subsequent placement of an artificial urinary sphincter or a urinary sling. … READ MORE …

The “best” way to measure post-treatment levels of urinary continence

A new paper published by researchers from Sweden’s prestigious Karolinska Institute and related institutions makes it increasingly clear that — to date — we haven’t been able to work out (let alone consistently use) a really good way to measure real urinary continence after radical prostatectomy. … READ MORE …

Incidence of climacturia “surprising” to one leading surgeon

It is sometimes amazing how little some physicians appear to understand about the side effects of the treatments that they give to their patients! If these were really rare side effects it might be understandable, but the one we shall discuss below is far from rare … … READ MORE …

Kegel exercises, incontinence, training, and recovery of continence after RP

A new study just published in The Lancet has reported that  — among men who have urinary incontinence 6 weeks after a radical prostatectomy (RP) — formal one-on-one training of patients by expert therapists does not in fact reduce the rate of continence at 12 months compared to patients in a control group. … READ MORE …

Duloxetine in treatment of mild to moderate post-surgical incontinence

Let us be clear up front … Duloxetine (Cymbalta®) has not been approved anywhere in the world that we are aware of as a treatment for post-surgical incontinence in men treated for prostate cancer, and there has never been a large, randomized, double-blind Phase III trial to try to demonstrate such activity. … READ MORE …

Age and risk for incontinence after radical prostatectomy

A new analysis of data from a large, consecutive series of Swedish patients suggests a very strong correlation between age at time of radical prostatectomy and risk for significant, long-term urinary leakage. … READ MORE …

How surgeons and patients think about post-surgical incontinence

We are coming to the conclusion that there is a deep divide between how some surgeons think about post-surgical incontinence following radical prostatectomy for their prostate cancer and how patients may think about such incontinence when defined by exactly the same set of clinical symptoms and quality of life issues. … READ MORE …

Side effects of surgery among patients diagnosed in the Göteborg screening trial

In July this year, we commented on the 14-year mortality data published by Hugosson et al. from the randomized, population-based, prostate cancer screening trial initiated in Göteborg, Sweden, in 1995. … READ MORE …

Duloxetine as a possible treatment for post-surgical incontinence

Duloxetine (Cymbalta®) is a drug that is approved in the USA for the treatment of depression, anxiety disorder, and certain specific types of pain. However, there are also data showing that it can be effective in the management of stress urinary incontinence (SUI) in women. … READ MORE …

Predicting time to recovery of continence after surgery

A group of German researchers has developed a method to predict the duration of urinary incontinence after radical prostatectomy based on potential risk factors. … READ MORE …

Dana Jennings is back …

… and this week he’s “Living with incontinence after prostate cancer.”